Chemistry:4-HO-NPT

From HandWiki

4-HO-NPT, also known as 4-hydroxy-N-propyltryptamine, is a serotonin receptor modulator and putative psychedelic drug of the tryptamine and 4-hydroxytryptamine families related to norpsilocin (4-HO-NMT).[1] It was not included by Alexander Shulgin in his 1997 book TiHKAL (Tryptamines I Have Known and Loved) and its properties and effects in humans are unknown.[2] The drug acts as a non-selective serotonin receptor agonist, including of the serotonin 5-HT2A receptor.[1] It produces the head-twitch response, a behavioral proxy of psychedelic effects, in rodents, albeit with about 26-fold lower potency than psilocin (4-HO-DMT).[1] Unlike 4-HO-NPT, norpsilocin is notably inactive in this test.[1] In addition to its psychedelic-like effects, 4-HO-NPT produces hypolocomotion and hypothermia in rodents.[1] 4-HO-NPT was first described in the scientific literature by Alexander Sherwood and colleagues by 2024.[1]

See also

References

  1. ↑ 1.0 1.1 1.2 1.3 1.4 1.5 "Psychedelic-like Activity of Norpsilocin Analogues". ACS Chemical Neuroscience 15 (2): 315–327. January 2024. doi:10.1021/acschemneuro.3c00610. PMID 38189238. 
  2. ↑ Shulgin, Alexander; Shulgin, Ann (September 1997). TiHKAL: The Continuation. Berkeley, California: Transform Press. ISBN 0-9630096-9-9. OCLC 38503252. http://www.erowid.org/library/books_online/tihkal/tihkal.shtml. 



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