Chemistry:4-HO-PiPT

From HandWiki

4-HO-PiPT, also known as 4-hydroxy-N-propyl-N-isopropyltryptamine or as piprocin, is a substituted tryptamine derivative which is claimed to have psychedelic effects.[1] It has been encountered as a novel designer drug.[2]

Use and effects

4-HO-EPT was not included nor mentioned in Alexander Shulgin's book TiHKAL (Tryptamines I Have Known and Loved).[3]

Interactions

Pharmacology

Pharmacodynamics

4-HO-PiPT acts as a serotonin 5-HT2A receptor agonist, with an EC50 of 13.8 nM and an efficacy of 104.8%.[4]

Chemistry

Analogues

Analogues of 4-HO-PiPT include propylisopropyltryptamine (PiPT), 5-MeO-PiPT, 4-HO-MiPT, 4-HO-EiPT, 4-HO-EiBT, 4-HO-DiPT, 4-HO-DsBT, 4-HO-McPT, and 4-HO-McPeT, among others.

History

4-HO-PiPT has been sold as a designer drug, first being identified in 2021 in British Columbia, Canada.[2]

Society and culture

Canada

4-HO-PiPT is not a controlled substance in Canada as of 2025.[5]

See also

References

  1. ↑ Morrison J. Glycosylated psilocin derivatives and methods of use. WO 2024/042239A1
  2. ↑ 2.0 2.1 "A Report on British Columbia's Unregulated Drug Supply. Drug checking trends across British Columbia, January to December 2021.". British Columbia Centre on Substance Use. June 2022. https://www.bccsu.ca/wp-content/uploads/2022/07/BCCSU_BCs_Annual_Drug_Checking_Report2022.pdf. 
  3. ↑ Shulgin, Alexander; Shulgin, Ann (September 1997). TiHKAL: The Continuation. Berkeley, California: Transform Press. ISBN 0-9630096-9-9. OCLC 38503252. http://www.erowid.org/library/books_online/tihkal/tihkal.shtml. 
  4. ↑ Banister S, Jorgensen W, Jinlong T. Compounds. Patent WO 2023/115167
  5. ↑ "Controlled Drugs and Substances Act". https://laws-lois.justice.gc.ca/eng/acts/c-38.8/FullText.html. 



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