Chemistry:5-MeO-PiPT

From HandWiki

5-MeO-PiPT, also known as 5-methoxy-N-propyl-N-isopropyltryptamine, is a substituted tryptamine derivative which is claimed to have psychedelic effects.[1][2] It has been sold as a designer drug, first being identified in 2021 in British Columbia, Canada.[3]

Use and effects

5-MeO-PiPT was not included nor mentioned in Alexander Shulgin's book TiHKAL (Tryptamines I Have Known and Loved).[4]

Interactions

Pharmacology

Pharmacodynamics

5-MeO-PiPT acts as a serotonin 5-HT1A and 5-HT2A receptor agonist,[1] with an EC50 of 13.8 nM and an efficacy of 89%.[2]

Chemistry

Analogues

Analogues of 5-MeO-PiPT include propylisopropyltryptamine (PiPT), 4-HO-PiPT, 5-MeO-DMT, 5-MeO-DPT, 5-MeO-DiPT, 5-MeO-MiPT, 5-MeO-EiPT, and 5-MeO-iPALT (ASR-3001), among others.

See also

References

  1. ↑ 1.0 1.1 "Structural pharmacology and therapeutic potential of 5-methoxytryptamines". Nature 630 (8015): 237–246. June 2024. doi:10.1038/s41586-024-07403-2. PMID 38720072. Bibcode: 2024Natur.630..237W. 
  2. ↑ 2.0 2.1 Patentscope. Banister S, Jorgensen W, Jinlong T. Compounds. Patent WO 2023/115167. Retrieved 2025-05-12
  3. ↑ "A Report on British Columbia's Unregulated Drug Supply. Drug checking trends across British Columbia, January to December 2021.". British Columbia Centre on Substance Use. June 2022. https://www.bccsu.ca/wp-content/uploads/2022/07/BCCSU_BCs_Annual_Drug_Checking_Report2022.pdf. 
  4. ↑ Shulgin, Alexander; Shulgin, Ann (September 1997). TiHKAL: The Continuation. Berkeley, California: Transform Press. ISBN 0-9630096-9-9. OCLC 38503252. http://www.erowid.org/library/books_online/tihkal/tihkal.shtml. 



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