Chemistry:7-Methyl-α-ethyltryptamine

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Short description: Chemical compound
7-Methyl-α-ethyltryptamine
7-Methyl-AET.svg
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
Chemical and physical data
FormulaC13H18N2
Molar mass202.301 g·mol−1
3D model (JSmol)

7-Methyl-α-ethyltryptamine (7-Me-αET) is a tryptamine derivative related to α-ethyltryptamine (αET). It was discovered by a team at Upjohn in the early 1960s.[1] It has similar pharmacological effects to αET, but is both 3-4 times more potent as a serotonin releasing agent, and 10 times more potent as a monoamine oxidase inhibitor,[2][3] making it potentially hazardous as this pharmacological profile is shared with drugs such as PMA and 4-MTA, which are known to be dangerous in humans when used at high doses.

See also

  • 4-Methyl-αET
  • 5-Fluoro-αMT
  • 5-Fluoro-αET
  • 7-Methyl-DMT
  • 7-Chloro-AMT

References

  1. U.S. Patent 3,296,072
  2. "Enzyme Inhibitory Activity of 3-(2-Aminobutyl)indole Derivatives". Journal of Medicinal Chemistry 7 (3): 274–9. May 1964. doi:10.1021/jm00333a006. PMID 14204959. 
  3. "Effect of Monase and related compounds on uptake of 5-hydroxytryptamine by platelets". Proceedings of the Society for Experimental Biology and Medicine 122 (3): 711–4. July 1966. doi:10.3181/00379727-122-31233. PMID 5918937.