Chemistry:Estradiol dibutyrate
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Short description: Chemical compound
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| Clinical data | |
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| Other names | EDBu; Estradiol dibutanoate; Estradiol 3,17β-dibutanoate |
| Routes of administration | Intramuscular injection |
| Drug class | Estrogen; Estrogen ester |
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| Chemical and physical data | |
| Formula | C26H36O4 |
| Molar mass | 412.570 g·mol−1 |
| 3D model (JSmol) | |
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Estradiol dibutyrate (EDBu), or estradiol dibutanoate, is an estrogen medication and an estrogen ester – specifically, a diester of estradiol – which is no longer used.[1][2] It was a component of Triormon Depositum, a combination formulation of estradiol dibutyrate, testosterone caproate, and hydroxyprogesterone heptanoate which was developed in the 1950s.[2]
See also
- List of estrogen esters § Estradiol esters
- Estradiol dibutyrate/hydroxyprogesterone heptanoate/testosterone caproate
References
- ↑ "[Experimental research on estradiol dibutyrate]" (in it). Minerva Ginecol 12: 788–9. August 1960. PMID 13689684.
- ↑ 2.0 2.1 "Triormon depositum in climacteric syndrome. Curves of excretion of catabolites and duration of the therapeutic effect". Quaderni Clin. Ostet. E Ginecol. 12: 284–93. 1957. "Triormon depositum (estradiol dibutyrate 3, testosterone caprylate 50, and hydroxyprogesterone heptanoate 30 mg.), administered in castor oil-benzyl benzoate soln. or polyvinylpyrrolidone suspension to 21 women in climacteric, was followed by estradiol, pregnanediol, and 17-keto steroid urinary curves, most with a peak at the 4th day, and approaching starting values at the 8-10th day. The therapeutic efficacy of the drug was satisfactory.".
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