Chemistry:L-741604

L-741604
Identifiers
	IUPAC name N,N-dimethyl-2-[5-(1,2,4-triazol-4-yl)-1H-indol-3-yl]ethanamine;
CAS Number	154594-22-6;
PubChem CID	9881526;
ChemSpider	8057202;
UNII	9IL3UOX666;
ChEMBL	ChEMBL296161;
Chemical and physical data
Formula	C14H17N5
Molar mass	255.325 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CN(C)CCC1=CNC2=C1C=C(C=C2)N3C=NN=C3;
	InChI InChI=1S/C14H17N5/c1-18(2)6-5-11-8-15-14-4-3-12(7-13(11)14)19-9-16-17-10-19/h3-4,7-10,15H,5-6H2,1-2H3; Key:IGNXHSPBUUSUHB-UHFFFAOYSA-N;

L-741,604 is an experimental drug from the substituted tryptamine family, which acts as an agonist for the 5-HT_1B and 5-HT_1D serotonin receptors, with around 6x selectivity for 5-HT_1D.^[1]^[2]^[3]

References

↑ "3-[2-(Pyrrolidin-1-yl)ethyl]indoles and 3-[3-(piperidin-1-yl)propyl]indoles: agonists for the h5-HT1D receptor with high selectivity over the h5-HT1B subtype". Journal of Medicinal Chemistry 40 (22): 3497–3500. October 1997. doi:10.1021/jm9704558. PMID 9357514.
↑ "Synthesis and serotonergic activity of 3-[2-(pyrrolidin-1-yl)ethyl]indoles: potent agonists for the h5-HT1D receptor with high selectivity over the h5-HT1B receptor". Journal of Medicinal Chemistry 42 (4): 677–690. February 1999. doi:10.1021/jm9805687. PMID 10052975.
↑ "3-(Piperazinylpropyl)indoles: selective, orally bioavailable h5-HT1D receptor agonists as potential antimigraine agents". Journal of Medicinal Chemistry 42 (4): 691–705. February 1999. doi:10.1021/jm980569z. PMID 10052976.

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Identifiers

IUPAC name N,N-dimethyl-2-[5-(1,2,4-triazol-4-yl)-1H-indol-3-yl]ethanamine
CAS Number	154594-22-6
PubChem CID	9881526
ChemSpider	8057202
UNII	9IL3UOX666
ChEMBL	ChEMBL296161
Chemical and physical data
Formula	C₁₄H₁₇N₅
Molar mass	255.325 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES CN(C)CCC1=CNC2=C1C=C(C=C2)N3C=NN=C3
InChI InChI=1S/C14H17N5/c1-18(2)6-5-11-8-15-14-4-3-12(7-13(11)14)19-9-16-17-10-19/h3-4,7-10,15H,5-6H2,1-2H3 Key:IGNXHSPBUUSUHB-UHFFFAOYSA-N