Chemistry:Salsolidine
From HandWiki
Salsolidine, also known as 6,7-dimethylsalsolinol, O-methylsalsoline, or norcarnegine, is a tetrahydroisoquinoline alkaloid found in various cactus species.[1][2] It is pharmacologically active.[1] Salsolidine has been found to act as a weak but relatively potent monoamine oxidase inhibitor (MAOI), specifically of monoamine oxidase A (MAO-A) ((R)-enantiomer Ki = 6 μM), among other actions.[1][3]
See also
References
- ↑ 1.0 1.1 1.2 Keeper Trout & friends (2013). Trout's Notes on The Cactus Alkaloids Nomenclature, Physical properties, Pharmacology & Occurrences (Sacred Cacti Fourth Edition, Part C: Cactus Chemistry: Section 1). Mydriatic Productions/Better Days Publishing. https://troutsnotes.com/pdf/C13_CactusAlkaloids.pdf.
- ↑ Menachery, Mary D.; Lavanier, Gregory L.; Wetherly, Mark L.; Guinaudeau, Hélène; Shamma, Maurice (1986). "Simple Isoquinoline Alkaloids". Journal of Natural Products 49 (5): 745–778. doi:10.1021/np50047a001. ISSN 0163-3864. Bibcode: 1986JNAtP..49..745M. https://pubs.acs.org/doi/abs/10.1021/np50047a001. Retrieved 20 May 2025.
- ↑ "Inhibition of monoamine oxidases A and B by simple isoquinoline alkaloids: racemic and optically active 1,2,3,4-tetrahydro-, 3,4-dihydro-, and fully aromatic isoquinolines". J Med Chem 33 (1): 147–152. January 1990. doi:10.1021/jm00163a025. PMID 2296014.
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