Chemistry:DU-125530

From HandWiki

DU-125530 is a drug which acts as a potent and selective 5-HT1A receptor antagonist. It has antidepressant effects in animal studies, as well as being used for basic research into the function of the 5-HT1A receptor.[1][2][3]

See also

References

  1. ↑ "The putative 5-HT1A receptor antagonist DU125530 blocks the discriminative stimulus of the 5-HT1A receptor agonist flesinoxan in pigeons". European Journal of Pharmacology 325 (2–3): 145–153. May 1997. doi:10.1016/s0014-2999(97)00131-3. PMID 9163561. 
  2. ↑ "5-Hydroxytryptamine1A receptor occupancy by novel full antagonist 2-[4-[4-(7-chloro-2,3-dihydro-1,4-benzdioxyn-5-yl)-1-piperazinyl]butyl]-1,2-benzisothiazol-3-(2H)-one-1,1-dioxide: a[11C][O-methyl-3H]-N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide trihydrochloride (WAY-100635) positron emission tomography study in humans". The Journal of Pharmacology and Experimental Therapeutics 301 (3): 1144–1150. June 2002. doi:10.1124/jpet.301.3.1144. PMID 12023549. 
  3. ↑ "Preclinical and clinical characterization of the selective 5-HT(1A) receptor antagonist DU-125530 for antidepressant treatment". British Journal of Pharmacology 167 (5): 1021–1034. November 2012. doi:10.1111/j.1476-5381.2011.01770.x. PMID 22050051. 



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