Chemistry:MM-77

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MM-77 is a piperazine derivative which is a serotonergic drug, acting as a potent and selective 5-HT1A receptor antagonist. It is used for research into the 5-HT1A receptor and has anxiolytic effects in animal models.[1][2][3][4][5][6]

See also

References

  1. ↑ "Behavioural profiles in the mouse defence test battery suggest anxiolytic potential of 5-HT(1A) receptor antagonists". Psychopharmacology 144 (2): 121–130. May 1999. doi:10.1007/s002130050984. PMID 10394992. 
  2. ↑ "The effects of compounds varying in selectivity as 5-HT(1A) receptor antagonists in three rat models of anxiety". Neuropharmacology 39 (10): 1848–1857. July 2000. doi:10.1016/s0028-3908(00)00074-5. PMID 10884565. 
  3. ↑ "Involvement of presynaptic 5-HT(1A) and benzodiazepine receptors in the anticonflict activity of 5-HT(1A) receptor antagonists". European Journal of Pharmacology 471 (1): 27–34. June 2003. doi:10.1016/s0014-2999(03)01814-4. PMID 12809949. 
  4. ↑ "The impact of spacer structure on 5-HT7 and 5-HT1A receptor affinity in the group of long-chain arylpiperazine ligands". Bioorganic & Medicinal Chemistry Letters 14 (23): 5863–5866. December 2004. doi:10.1016/j.bmcl.2004.09.029. PMID 15501057. 
  5. ↑ "Effect of the postsynaptic 5-HT1A receptor antagonist MM-77 on stressed mice treated with 5-HT1A receptor agents". European Journal of Pharmacology 508 (1–3): 155–158. January 2005. doi:10.1016/j.ejphar.2004.12.013. PMID 15680266. 
  6. ↑ "Adrenalectomy modifies the hippocampal 5-HT(1A) receptors and the anxiolytic-like effect of 8-OH-DPAT in rats". Pharmacology, Biochemistry, and Behavior 92 (1): 182–189. March 2009. doi:10.1016/j.pbb.2008.11.008. PMID 19095004. 



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