Chemistry:SDZ-216-525

From HandWiki

SDZ-216-525 is a serotonergic drug derived from the phenylpiperazine family which is used in scientific research. It acts as a potent and selective 5-HT1A receptor antagonist, and is used for research into the function of the 5-HT1A receptor.[1][2][3][4][5][6]

See also

References

  1. ↑ "SDZ 216-525, a selective and potent 5-HT1A receptor antagonist". European Journal of Pharmacology 244 (3): 251–257. February 1993. doi:10.1016/0922-4106(93)90150-8. PMID 8384569. 
  2. ↑ "Induction of hypothermia as a model of 5-hydroxytryptamine1A receptor-mediated activity in the rat: a pharmacological characterization of the actions of novel agonists and antagonists". The Journal of Pharmacology and Experimental Therapeutics 264 (3): 1364–1376. March 1993. doi:10.1016/S0022-3565(25)10153-5. PMID 8450471. 
  3. ↑ "Further assessment of the antagonist properties of the novel and selective 5-HT1A receptor ligands (+)-WAY 100 135 and SDZ 216-525". European Journal of Pharmacology 249 (1): 25–35. November 1993. doi:10.1016/0014-2999(93)90658-5. PMID 8282017. 
  4. ↑ "In vivo characterization of the putative 5-HT1A receptor antagonist SDZ 216,525 using two models of somatodendritic 5-HT1A receptor function". Neuropharmacology 33 (3–4): 359–366. 1994. doi:10.1016/0028-3908(94)90066-3. PMID 7984274. 
  5. ↑ "A drug discrimination analysis of the actions of novel serotonin1A receptor ligands in the rat using the 5-HT1A receptor agonist, 8-hydroxy-2-(di-n-propylamino)tetralin". The Journal of Pharmacology and Experimental Therapeutics 275 (2): 822–831. November 1995. doi:10.1016/S0022-3565(25)12134-4. PMID 7473172. 
  6. ↑ "Influence of 5-HT1A receptor antagonism on plus-maze behaviour in mice. II. WAY 100635, SDZ 216-525 and NAN-190". Pharmacology, Biochemistry, and Behavior 58 (2): 593–603. October 1997. doi:10.1016/s0091-3057(97)00279-7. PMID 9300624. 



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