Chemistry:Cianergoline

From HandWiki

Cianergoline (INN), also known as 355/1057 or as 2-cyano-3-(6-methylergolin-8β-yl)propionamide (2-CMEBP), is a dopamine receptor agonist described as an antihypertensive agent of the ergoline family which was never marketed.[1][2][3] It has atypical properties as a dopamine receptor agonist compared to other ergolines, for instance having less central activity and showing predominant cardiovascular effects.[3] In addition to its dopamine receptor agonism, cianergoline may interact with α-adrenergic receptors, which may or may not also be involved in its antihypertensive effects.[3][4][5] The drug was first described in the scientific literature by 1983.[1][6][2] It was studied for treatment of essential hypertension.[3]

See also

  • Substituted ergoline

References

  1. ↑ 1.0 1.1 The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. 14 November 2014. ISBN 978-1-4757-2085-3. https://books.google.com/books?id=0vXTBwAAQBAJ&pg=PA270. Retrieved 6 May 2026. 
  2. ↑ 2.0 2.1 Riva, F., & Sardi, A. (1984). Cianergoline. Drugs of the Future, 9, 13. https://scholar.google.com/scholar?cluster=14938482905837820153
  3. ↑ 3.0 3.1 3.2 3.3 "Effects of the dopaminergic agonist cianergoline on blood pressure, the renin-angiotensin-aldosterone axis and the sympathetic nervous system in patients with essential hypertension". European Journal of Clinical Pharmacology 29 (1): 25–31. 1985. doi:10.1007/BF00547364. PMID 4054204. 
  4. ↑ "Cianergoline lowers intraocular pressure in rabbits and monkeys and inhibits contraction of the cat nictitans by suppressing sympathetic neuronal function". Journal of Ocular Pharmacology 3 (4): 309–321. 1987. doi:10.1089/jop.1987.3.309. PMID 3503920. 
  5. ↑ "Involvement of peripheral dopamine receptors in the antihypertensive effect of a new ergoline derivative (355/1057)". Archives Internationales de Pharmacodynamie et de Therapie 274 (2): 291–304. April 1985. PMID 4026460. 
  6. ↑ "Cardiovascular effects of a new antihypertensive agent in several species". Arzneimittel-Forschung 33 (8): 1098–1106. 1983. PMID 6685486. 



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