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Short description: Chemical compound
Crotylbarbital![Crotylbarbital.svg](/wiki/images/thumb/8/8f/Crotylbarbital.svg/140px-Crotylbarbital.svg.png) |
Clinical data |
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Identifiers |
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5-but-2-enyl-5-ethyl-1,3-diazinane-2,4,6-trione
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Chemical and physical data |
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Formula | C10H14N2O3 |
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Molar mass | 210.233 g·mol−1 |
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3D model (JSmol) | |
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O=C1NC(=O)NC(=O)C1(CC)C/C=C/C
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InChI=1S/C10H14N2O3/c1-3-5-6-10(4-2)7(13)11-9(15)12-8(10)14/h3,5H,4,6H2,1-2H3,(H2,11,12,13,14,15)/b5-3+ YKey:KNMOHCLEINXVBG-HWKANZROSA-N Y
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Crotylbarbital (Mepertan, Kalipnon, Barotal), also known as crotarbital, is a barbiturate derivative developed by Eli Lilly in the 1930s.[1] It has sedative and hypnotic effects,[2] and was used for the treatment of insomnia until it was replaced by newer alternative drugs with fewer side effects and lower risk of overdose.
See also
References
- ↑ Shonle HA, Doran WJ, "Alkyl-crotyl barbituric acids and their salts", US patent 2250422, issued 22 July 1941, assigned to Eli Lilly
- ↑ "Effect of an acute dose of crotylbarbital on reaction time and attention testing in healthy human subjects". International Journal of Clinical Pharmacology, Therapy, and Toxicology 21 (6): 306–10. June 1983. PMID 6136469.
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Barbiturates | |
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Volatiles/gases | |
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Others/unsorted |
- 3-Hydroxybutanal
- α-EMTBL
- AA-29504
- Avermectins (e.g., ivermectin)
- Bromide compounds (e.g., lithium bromide, potassium bromide, sodium bromide)
- Carbamazepine
- Chloralose
- Chlormezanone
- Clomethiazole
- DEABL
- Dihydroergolines (e.g., dihydroergocryptine, dihydroergosine, dihydroergotamine, ergoloid (dihydroergotoxine))
- DS2
- Efavirenz
- Etazepine
- Etifoxine
- Fenamates (e.g., flufenamic acid, mefenamic acid, niflumic acid, tolfenamic acid)
- Fluoxetine
- Flupirtine
- Hopantenic acid
- Lanthanum
- Lavender oil
- Lignans (e.g., 4-O-methylhonokiol, honokiol, magnolol, obovatol)
- Loreclezole
- Menthyl isovalerate (validolum)
- Monastrol
- Niacin
- Nicotinamide (niacinamide)
- Org 25,435
- Phenytoin
- Propanidid
- Retigabine (ezogabine)
- Safranal
- Seproxetine
- Stiripentol
- Sulfonylalkanes (e.g., sulfonmethane (sulfonal), tetronal, trional)
- Terpenoids (e.g., borneol)
- Topiramate
- Valerian constituents (e.g., isovaleric acid, isovaleramide, valerenic acid, valerenol)
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