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Short description
Proxibarbital Clinical data Other names Proxibarbital, Centralgol, Ipronal, 5-Allyl-5-(β-hydroxypropyl)barbituric acid ATC code Identifiers
(RS )-5-allyl-5-(2-hydroxypropyl)pyrimidine-2,4,6(1H ,3H ,5H )-trione
CAS Number PubChem CID ChemSpider UNII ChEMBL Chemical and physical data Formula C 10 H 14 N 2 O 4 Molar mass −1 3D model (JSmol )
O=C1NC(=O)NC(=O)C1(CC(O)C)C\C=C
InChI=1S/C10H14N2O4/c1-3-4-10(5-6(2)13)7(14)11-9(16)12-8(10)15/h3,6,13H,1,4-5H2,2H3,(H2,11,12,14,15,16)
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Proxibarbital (Ipronal) is a barbiturate derivative synthesized in 1956. It has anti-anxiety properties and is, in contrast to most barbiturates, almost without hypnotic action.[1]
It was also used in the treatment of migraine headaches in a similar manner to butalbital .[2]
Valofane isomerises to Proxibarbal in vivo.
References
↑ (in polish) Chemia leków, podręcznik dla studentów farmacji i farmaceutów . Warszawa, Poland. 2008. ISBN 978-83-200-3652-7 . ↑ "[Migraine therapy by enzyme induction with proxibarbital]" (in German). Therapie der Gegenwart 115 (12): 2088–103. December 1976. PMID 14412 .
Alcohols Barbiturates Benzodiazepines Carbamates Flavonoids Imidazoles Kava constituentsMonoureides Neuroactive steroids Nonbenzodiazepines Phenols Piperidinediones Pyrazolopyridines Quinazolinones Volatiles /gases Others/unsorted
3-Hydroxybutanal α-EMTBL AA-29504 Avermectins (e.g., ivermectin )Bromide compounds (e.g., lithium bromide , potassium bromide , sodium bromide) Carbamazepine Chloralose Chlormezanone Clomethiazole DEABL Dihydroergolines (e.g., dihydroergocryptine , dihydroergosine , dihydroergotamine , ergoloid (dihydroergotoxine) )DS2 Efavirenz Etazepine Etifoxine Fenamates (e.g., flufenamic acid , mefenamic acid , niflumic acid , tolfenamic acid )Fluoxetine Flupirtine Hopantenic acid Lanthanum Lavender oil Lignans (e.g., 4-O-methylhonokiol , honokiol , magnolol , obovatol )Loreclezole Menthyl isovalerate (validolum) Monastrol Niacin Nicotinamide (niacinamide) Org 25,435 Phenytoin Propanidid Retigabine (ezogabine) Safranal Seproxetine Stiripentol Sulfonylalkanes (e.g., sulfonmethane (sulfonal) , tetronal , trional )Terpenoids (e.g., borneol )Topiramate Valerian constituents (e.g., isovaleric acid , isovaleramide , valerenic acid , valerenol )
Original source: https://en.wikipedia.org/wiki/Proxibarbital. Read more
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