Chemistry:Glufimet

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Short description: Chemical compound
Glufimet
Clinical data
Other namesRGPU-238; Dimethyl 3-phenylglutamic acid hydrochloride; Dimethyl 3-phenylglutamate hydrochloride; 1,5-Dimethyl (2S)-2-amino-3-phenylpentanedioate hydrochloride
Identifiers
CAS Number
PubChem CID
ChemSpider
Chemical and physical data
FormulaC13H18ClNO4
Molar mass287.74 g·mol−1
3D model (JSmol)

Glufimet (developmental code name RGPU-238), also known as dimethyl 3-phenylglutamate hydrochloride, is a derivative of glutamic acid (glutamate) which was developed in Russia and is related to the γ-aminobutyric acid (GABA) derivative phenibut (3-phenyl-GABA).[1][2][3][4] It contains phenibut and glycine fragments in its chemical structure, has been described, as a "GABA precursor", and is said to modulate the GABA and nitric oxide (NO) systems and to have antioxidant activity.[1][2][3][4] It has been suggested that metabotropic glutamate receptors may also play a role in the mechanism of action of glufimet.[4] Stress-protective effects have been described for glufimet in animals.[1][2][3]

References

  1. ↑ 1.0 1.1 1.2 "Effects of a New Glutamic Acid Derivative on Myocardial Contractility of Stressed Animals under Conditions of Nitric Oxide Synthesis Blockade". Bull. Exp. Biol. Med. 159 (3): 384–6. July 2015. doi:10.1007/s10517-015-2969-7. PMID 26205724. 
  2. ↑ 2.0 2.1 2.2 "Effect of Phenibut and Glufimet, a Novel Glutamic Acid Derivative, on Respiration of Heart and Brain Mitochondria from Animals Exposed to Stress against the Background of Inducible NO-Synthase Blockade". Bull. Exp. Biol. Med. 163 (2): 226–229. June 2017. doi:10.1007/s10517-017-3772-4. PMID 28726197. 
  3. ↑ 3.0 3.1 3.2 "[Cardioprotective effect of the new derivative of glutamic acid - glufimet in acute immobilization-painful stress in animals of different ages]" (in ru). Adv Gerontol 29 (1): 116–122. 2016. doi:10.1134/S2079057016030073. PMID 28423256. 
  4. ↑ 4.0 4.1 4.2 "Inhibition of the Expression of Inducible NO Synthase by Neuroactive Amino Acid Derivatives Phenibut and Glufimet In Vitro and Ex Vivo". Bull. Exp. Biol. Med. 164 (2): 177–180. December 2017. doi:10.1007/s10517-017-3952-2. PMID 29181662. 


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See also
Receptor/signaling modulators
GABAA receptor positive modulators
GABA metabolism/transport modulators

}}




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