Chemistry:HQ-355
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HQ-355, is an analogue of the sedative and hypnotic drug methaqualone developed in the late 1970s. It is a derivative of methaqualone substituted with a fluorine on the 2-methyl group. It has similar effects to methaqualone in animal studies but with slightly higher potency and an improved side effect profile. HQ-355 itself was never developed for medical uses, but its 6-amino derivative afloqualone did pass human trials and has seen some limited clinical application as a muscle relaxant.[1][2][3]
See also
- List of methaqualone analogues
References
- ↑ "Synthesis and central nervous system activity of quinazolones related to 2-methyl-3-(o-tolyl)-4(3H)-quinazolone (methaqualone)". Journal of Medicinal Chemistry 20 (3): 379–386. March 1977. doi:10.1021/jm00213a013. PMID 845871.
- ↑ "Studies on biologically active halogenated compounds. 1. Synthesis and central nervous system depressant activity of 2-(fluoromethyl)-3-aryl-4(3H)-quinazolinone derivatives". Journal of Medicinal Chemistry 22 (1): 95–99. January 1979. doi:10.1021/jm00187a021. PMID 423189.
- ↑ "Pharmacology of a new hypnotic drug: HQ-355". Japanese Journal of Pharmacology 22 (3): 431–434. June 1972. doi:10.1254/jjp.22.431. PMID 4539402.
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