Chemistry:Estradiol 3-glucuronide 17β-sulfate
From HandWiki
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| Names | |
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| IUPAC name
17β-(Sulfooxy)estra-1,3,5(10)-trien-3-yl β-D-glucopyranosiduronic acid
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| Systematic IUPAC name
(2S,3S,4S,5R,6S)-3,4,5-Trihydroxy-6-{[(1S,3aS,3bR,9bS,11aS)-11a-methyl-1-(sulfooxy)-2,3,3a,3b,4,5,9b,10,11,11a-decahydro-1H-cyclopenta[a]phenanthren-7-yl]oxy}oxane-2-carboxylic acid | |
| Other names
E2-3G-17S
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| Identifiers | |
3D model (JSmol)
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PubChem CID
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| Properties | |
| C24H32O11S | |
| Molar mass | 528.57 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
| Infobox references | |
Estradiol 3-glucuronide 17β-sulfate (E2-3G-17S) is an endogenous estrogen conjugate and metabolite of estradiol.[1][2] It is related to estradiol 3-sulfate and estradiol 17β-glucuronide.[1][2] Estradiol 3-glucuronide 17β-sulfate has 0.0001% of the relative binding affinity of estradiol for the ERα, one of the two estrogen receptors (ERs).[3] It shows less than one million-fold lower potency in activating the estrogen receptors relative to estradiol in vitro.[4]
See also
References
- ↑ 1.0 1.1 "Determination of estrogens and their conjugates in water using solid-phase extraction followed by liquid chromatography-tandem mass spectrometry". J Chromatogr A 984 (2): 195–202. January 2003. doi:10.1016/s0021-9673(02)01851-4. PMID 12564690.
- ↑ 2.0 2.1 "Simultaneous determination of 16 estrogens, dehydroepiandrosterone and their glucuronide and sulfate conjugates in serum using sodium cholate micelle capillary electrophoresis". Biomed. Chromatogr. 17 (4): 263–7. June 2003. doi:10.1002/bmc.236. PMID 12833391.
- ↑ "Hands-off linear interaction energy approach to binding mode and affinity estimation of estrogens". J Chem Inf Model 53 (10): 2681–8. October 2013. doi:10.1021/ci400392p. PMID 24063761.
- ↑ "Evaluation of a recombinant yeast cell estrogen screening assay". Environ. Health Perspect. 105 (7): 734–42. July 1997. doi:10.1289/ehp.97105734. PMID 9294720.
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