Chemistry:Dextromethadone
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| Other names | d-Methadone; 6S-Methadone; (+)-Methadone |
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| Formula | C21H27NO |
| Molar mass | 309.453 g·mol−1 |
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Dextromethadone (developmental code name REL-1017) is the (S)-enantiomer of methadone. It acts as an N-methyl-D-aspartate receptor (NMDAR) antagonist.[1] Unlike levomethadone, it has low affinity for opioid receptors and lacks significant respiratory depressant action and abuse liability.[2][3] Dextromethadone is under development for the treatment of major depressive disorder.[4] There is an asymmetric synthesis available to prepare both dextromethadone (S-(+)-methadone) and levomethadone (R-(−)-methadone).[5][6]
References
- ↑ Cite error: Invalid
<ref>tag; no text was provided for refs namedpmid9058409 - ↑ "METHADONE". Drug Enforcement Agency. https://www.deadiversion.usdoj.gov/drug_chem_info/methadone/methadone.pdf#search=methadone.
- ↑ Cite error: Invalid
<ref>tag; no text was provided for refs namedpmid7562497 - ↑ https://adisinsight.springer.com/drugs/800038927
- ↑ "Synthesis of optically active methadones, LAAM and bufuralol by lipase-catalysed acylations". Tetrahedron: Asymmetry 14 (5): 567–576. March 2003. doi:10.1016/S0957-4166(03)00019-3.
- ↑ US patent 6143933
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