Chemistry:DopAmide

DopAmide, or L-DopAmide, is a synthetic levodopa (L-DOPA) analogue that can serve as a levodopa and dopamine prodrug and is of potential interest in the treatment of Parkinson's disease.^[1]^[2]^[3] DopAmide has an amide rather than the carboxyl group of L-DOPA,^[2]^[3] which imparts greater water solubility.^[1]^[2]^[3] The amide is hydrolyzed back to the acid by aminopeptidase enzymes.^[1]^[2]^[3]

References

↑ ^1.0 ^1.1 ^1.2 "Prodrug Strategies in the CNS Drugs: Small Modification Makes Big Improvements". Current Topics in Medicinal Chemistry 21 (24): 2157–2169. 2021. doi:10.2174/1568026621666210727163827. PMID 34315372.
↑ ^2.0 ^2.1 ^2.2 ^2.3 "Improving the Delivery of Levodopa in Parkinson's Disease: A Review of Approved and Emerging Therapies". CNS Drugs 34 (11): 1149–1163. November 2020. doi:10.1007/s40263-020-00769-7. PMID 33146817.
↑ ^3.0 ^3.1 ^3.2 ^3.3 "DopAmide: Novel, Water-Soluble, Slow-Release l-dihydroxyphenylalanine (l-DOPA) Precursor Moderates l-DOPA Conversion to Dopamine and Generates a Sustained Level of Dopamine at Dopaminergic Neurons". CNS Neuroscience & Therapeutics 22 (6): 461–467. June 2016. doi:10.1111/cns.12518. PMID 26861609.

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[KangMiaoLiu2021-1] 1.0 ^1.1 ^1.2 "Prodrug Strategies in the CNS Drugs: Small Modification Makes Big Improvements". Current Topics in Medicinal Chemistry 21 (24): 2157–2169. 2021. doi:10.2174/1568026621666210727163827. PMID 34315372.

[UrsoChaudhuriQamar2020-2] 2.0 ^2.1 ^2.2 ^2.3 "Improving the Delivery of Levodopa in Parkinson's Disease: A Review of Approved and Emerging Therapies". CNS Drugs 34 (11): 1149–1163. November 2020. doi:10.1007/s40263-020-00769-7. PMID 33146817.

[Atlas2016-3] 3.0 ^3.1 ^3.2 ^3.3 "DopAmide: Novel, Water-Soluble, Slow-Release l-dihydroxyphenylalanine (l-DOPA) Precursor Moderates l-DOPA Conversion to Dopamine and Generates a Sustained Level of Dopamine at Dopaminergic Neurons". CNS Neuroscience & Therapeutics 22 (6): 461–467. June 2016. doi:10.1111/cns.12518. PMID 26861609.

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