Biology:Brain-specific angiogenesis inhibitor 2

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Short description: Protein-coding gene in the species Homo sapiens


A representation of the 3D structure of the protein myoglobin showing turquoise α-helices.
Generic protein structure example

Brain-specific angiogenesis inhibitor 2 is a protein that in humans is encoded by the BAI2 gene.[1][2] It is a member of the adhesion-GPCR family of receptors.[3]

BAI1, a p53-target gene, encodes brain-specific angiogenesis inhibitor, a seven-span transmembrane protein and is thought to be a member of the secretin receptor family. Brain-specific angiogenesis proteins BAI2 and BAI3 are similar to BAI1 in structure, have similar tissue specificities and may also play a role in angiogenesis.[2]

References

  1. ↑ "Cloning and characterization of BAI2 and BAI3, novel genes homologous to brain-specific angiogenesis inhibitor 1 (BAI1)". Cytogenet Cell Genet 79 (1–2): 103–8. Apr 1998. doi:10.1159/000134693. PMID 9533023. 
  2. ↑ 2.0 2.1 "Entrez Gene: BAI2 brain-specific angiogenesis inhibitor 2". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=576. 
  3. ↑ Stacey, edited by Simon Yona, Martin (2010). Adhesion-GPCRs : structure to function. New York: Springer Science+Business Media. ISBN 9781441979124. 

External links

Further reading

  • "The calcium-independent receptor for alpha-latrotoxin from human and rodent brains interacts with members of the ProSAP/SSTRIP/Shank family of multidomain proteins.". J. Biol. Chem. 275 (42): 32387–90. 2000. doi:10.1074/jbc.C000490200. PMID 10964907. 
  • "Expression of brain-specific angiogenesis inhibitor 2 (BAI2) in normal and ischemic brain: involvement of BAI2 in the ischemia-induced brain angiogenesis.". J. Cereb. Blood Flow Metab. 22 (9): 1054–67. 2002. doi:10.1097/00004647-200209000-00003. PMID 12218411. 
  • "Functional interaction of megalin with the megalinbinding protein (MegBP), a novel tetratrico peptide repeat-containing adaptor molecule.". J. Cell Sci. 116 (Pt 3): 453–61. 2003. doi:10.1242/jcs.00243. PMID 12508107. 
  • "Toward a human blood serum proteome: analysis by multidimensional separation coupled with mass spectrometry.". Mol. Cell. Proteomics 1 (12): 947–55. 2003. doi:10.1074/mcp.M200066-MCP200. PMID 12543931. 
  • "Chromosome 13q12 encoded Rho GTPase activating protein suppresses growth of breast carcinoma cells, and yeast two-hybrid screen shows its interaction with several proteins.". Biochem. Biophys. Res. Commun. 313 (3): 654–65. 2004. doi:10.1016/j.bbrc.2003.12.001. PMID 14697242. 
  • "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039. 
  • "The human and mouse repertoire of the adhesion family of G-protein-coupled receptors.". Genomics 84 (1): 23–33. 2005. doi:10.1016/j.ygeno.2003.12.004. PMID 15203201. 


This article incorporates text from the United States National Library of Medicine, which is in the public domain.




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