Biology:GPR34
From HandWiki
Short description: Protein-coding gene in humans
 Generic protein structure example |
Probable G-protein coupled receptor 34 is a protein that in humans is encoded by the GPR34 gene.[1][2][3] The receptor binds to lysophosphatidylserine. [4]
Function
G protein-coupled receptors (GPCRs), such as GPR34, are integral membrane proteins containing 7 putative transmembrane domains (TMs). These proteins mediate signals to the interior of the cell via activation of heterotrimeric G proteins that in turn activate various effector proteins, ultimately resulting in a physiologic response.[supplied by OMIM][3]
References
- ↑ "A novel subgroup of class I G-protein-coupled receptors". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression 1446 (1–2): 57–70. July 1999. doi:10.1016/s0167-4781(99)00081-0. PMID 10395919.
- ↑ "Discovery of three novel orphan G-protein-coupled receptors". Genomics 56 (1): 12–21. February 1999. doi:10.1006/geno.1998.5655. PMID 10036181.
- ↑ 3.0 3.1 "Entrez Gene: GPR34 G protein-coupled receptor 34". https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=2857.
- ↑ Sugo T, Tachimoto H, Chikatsu T, Murakami Y, Kikukawa Y, Sato S (2006). "Identification of a lysophosphatidylserine receptor on mast cells.". Biochem Biophys Res Commun 341 (4): 1078–87. doi:10.1016/j.bbrc.2006.01.069. PMID 16460680. Bibcode: 2006BBRC..341.1078S. https://linkinghub.elsevier.com/retrieve/pii/S0006-291X(06)00158-6.
Further reading
- "Generation and analysis of 280,000 human expressed sequence tags". Genome Research 6 (9): 807–28. September 1996. doi:10.1101/gr.6.9.807. PMID 8889549.
- "Physical mapping and exclusion of GPR34 as the causative gene for congenital stationary night blindness type 1". Human Genetics 107 (1): 89–91. July 2000. doi:10.1007/s004390050017. PMID 10982042.
- "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Research 12 (2): 117–26. 2007. doi:10.1093/dnares/12.2.117. PMID 16303743.
- "Genomic and supragenomic structure of the nucleotide-like G-protein-coupled receptor GPR34". Genomics 87 (2): 254–64. February 2006. doi:10.1016/j.ygeno.2005.10.001. PMID 16338117.
- "Transcriptome analysis of human gastric cancer". Mammalian Genome 16 (12): 942–54. December 2005. doi:10.1007/s00335-005-0075-2. PMID 16341674.
- "Altered immune response in mice deficient for the G protein-coupled receptor GPR34". The Journal of Biological Chemistry 286 (3): 2101–10. January 2011. doi:10.1074/jbc.M110.196659. PMID 21097509.
- "The ligand specificity of the G-protein-coupled receptor GPR34". The Biochemical Journal 443 (3): 841–50. May 2012. doi:10.1042/BJ20112090. PMID 22348703.
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