Biology:S1PR5

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Sphingosine-1-phosphate receptor 5 also known as S1PR5 is a human gene which encodes a G protein-coupled receptor which binds the lipid signaling molecule sphingosine 1-phosphate (S1P). Hence this receptor is also known as S1P₅.

Agonists

• A-971432
• Sphingosine 1-phosphate receptor agonists: a patent review (2010-2012)

Evolution

Paralogues for S1PR5 Gene

• S1PR1
• S1PR3
• S1PR2
• S1PR4
• LPAR1
• LPAR2
• GPR3
• LPAR3
• GPR12
• CNR1
• GPR6
• CNR2
• MC4R
• MC3R
• MC5R
• GPR119
• MC1R
• MC2R

See also

• Lysophospholipid receptor

Further reading

• "Characterization of a novel sphingosine 1-phosphate receptor, Edg-8". The Journal of Biological Chemistry 275 (19): 14281–6. May 2000. doi:10.1074/jbc.275.19.14281. PMID 10799507. 
• "Nrg-1 belongs to the endothelial differentiation gene family of G protein-coupled sphingosine-1-phosphate receptors". The Journal of Biological Chemistry 276 (8): 5692–9. Feb 2001. doi:10.1074/jbc.M003964200. PMID 11069896. 
• "Sphingosine 1-phosphate receptors". Prostaglandins 64 (1–4): 135–142. Apr 2001. doi:10.1016/s0090-6980(01)00109-5. PMID 11331101. 
• "Characterization of the human and mouse sphingosine 1-phosphate receptor, S1P5 (Edg-8): structure-activity relationship of sphingosine1-phosphate receptors". Biochemistry 40 (46): 14053–60. Nov 2001. doi:10.1021/bi011606i. PMID 11705398. 
• "Identification of G protein-coupled receptor genes from the human genome sequence". FEBS Letters 520 (1–3): 97–101. Jun 2002. doi:10.1016/S0014-5793(02)02775-8. PMID 12044878. 
• "Comparative analysis of human and rat S1P(5) (edg8): differential expression profiles and sensitivities to antagonists". Biochemical Pharmacology 64 (8): 1243–50. Oct 2002. doi:10.1016/S0006-2952(02)01289-3. PMID 12234605. 
• "Characterization of a human sphingosine-1-phosphate receptor gene (S1P5) and its differential expression in LGL leukemia". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression 1579 (2–3): 117–23. Dec 2002. doi:10.1016/S0167-4781(02)00529-8. PMID 12427546. 
• "Sphingosine-1-phosphate and its potentially paradoxical effects on critical parameters of cutaneous wound healing". The Journal of Investigative Dermatology 120 (4): 693–700. Apr 2003. doi:10.1046/j.1523-1747.2003.12096.x. PMID 12648236. 
• "Evidence for the presence of the sphingosine-1-phosphate receptor Edg-8 in human radial glial fibers". Acta Histochemica 106 (5): 373–8. 2005. doi:10.1016/j.acthis.2004.08.002. PMID 15530552. 
• "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. Oct 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R. 
• "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Research 12 (2): 117–26. 2007. doi:10.1093/dnares/12.2.117. PMID 16303743. 
• "The use of selective sphingosine-1-phosphate receptor 5 agonists for the treatment of neurodegenerative disorders such as alzheimer's disease and lysosomal storage diseases such as niemann-pick c disease". Alzheimer's & Dementia 10: P281. Jun 2014. doi:10.1016/j.jalz.2014.07.153. 
• "T-bet-dependent S1P5 expression in NK cells promotes egress from lymph nodes and bone marrow". J Exp Med 206 (11): 2469–81. Oct 2009. doi:10.1084/jem.20090525. PMID 19808259. 

External links

• "Lysophospholipid Receptors: S₁P₅". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2997. 
• Lysophospholipid+receptors at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.