Biology:GPR146
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
G-protein coupled receptor 146 is a protein that in humans is encoded by the GPR146 gene.[1] The receptor has been shown to bind cholesin/C7orf50, a gut-derived hormone that is secreted from the intestine in response to dietary cholesterol absorption. In response to cholesin binding, GPR146 signaling inhibit cholesterol synthesis.[2] Consistent with this interaction, murine genetic disruption of GPR146 lowers serum cholesterol and reduces atherosclerotic aortic lesions.[3] GPR146 has also been identified as a possible receptor for C-peptide.[4]
References
- ↑ "Entrez Gene: GPR146 G protein-coupled receptor 146". https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=115330.
- ↑ Hu X, Chen F, Jia L, Long A, Peng Y, Li X (2024). "A gut-derived hormone regulates cholesterol metabolism.". Cell 187 (7): 1685-1700.e18. doi:10.1016/j.cell.2024.02.024. PMID 38503280. https://linkinghub.elsevier.com/retrieve/pii/S0092-8674(24)00226-5.
- ↑ Yu H, Rimbert A, Palmer AE, Toyohara T, Xia Y, Xia F (2019). "GPR146 Deficiency Protects against Hypercholesterolemia and Atherosclerosis.". Cell 179 (6): 1276-1288.e14. doi:10.1016/j.cell.2019.10.034. PMID 31778654. PMC 6889877. https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=31778654.
- ↑ "Evidence for an interaction between proinsulin C-peptide and GPR146". The Journal of Endocrinology 218 (2): B1-8. 11 July 2013. doi:10.1530/JOE-13-0203. PMID 23759446. http://joe.endocrinology-journals.org/content/218/2/B1.long.
Further reading
- "The G protein-coupled receptor repertoires of human and mouse". Proceedings of the National Academy of Sciences of the United States of America 100 (8): 4903–8. Apr 2003. doi:10.1073/pnas.0230374100. PMID 12679517. Bibcode: 2003PNAS..100.4903V.
- "Nine new human Rhodopsin family G-protein coupled receptors: identification, sequence characterisation and evolutionary relationship". Biochimica et Biophysica Acta (BBA) - General Subjects 1722 (3): 235–46. Apr 2005. doi:10.1016/j.bbagen.2004.12.001. PMID 15777626.
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