Biology:GPR161
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
G-protein coupled receptor 161 is a protein that in humans is encoded by the GPR161 gene.[1][2] It is located on primary cilia and regulates embryonic development through suppression of the hedgehog signaling pathway. It appears to act as a mechanoreceptor and may not require an endogenous ligand for activation.[3][4][5][6]
References
- ↑ "False positive non-synonymous polymorphisms of G-protein coupled receptor genes". FEBS Letters 516 (1–3): 253–256. Apr 2002. doi:10.1016/S0014-5793(02)02564-4. PMID 11959142. Bibcode: 2002FEBSL.516..253S.
- ↑ "Entrez Gene: GPR161 G protein-coupled receptor 161". https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=23432.
- ↑ "Hedgehog and Gpr161: Regulating cAMP Signaling in the Primary Cilium". Cells 9 (1): 118. 2020. doi:10.3390/cells9010118. PMID 31947770.
- ↑ "Primary cilia, A-kinase anchoring proteins and constitutive activity at the orphan G protein-coupled receptor GPR161: A tale about a tail". British Journal of Pharmacology 181 (14): 2182–2196. 2024. doi:10.1111/bph.16053. PMID 36772847.
- ↑ "GPR161 structure uncovers the redundant role of sterol-regulated ciliary cAMP signaling in the Hedgehog pathway". Nature Structural & Molecular Biology 31 (4): 667–677. 2024. doi:10.1038/s41594-024-01223-8. PMID 38326651.
- ↑ "GPR161 mechanosensitivity at the primary cilium drives neuronal saltatory migration". Science Advances 11 (31). 2025. doi:10.1126/sciadv.adx3846. PMID 40737401.
Further reading
- "The structural basis of G-protein-coupled receptor function and dysfunction in human diseases". Reviews of Physiology, Biochemistry and Pharmacology. 144. 2002. pp. 143–227. doi:10.1007/BFb0116587. ISBN 978-3-540-42814-5.
- "Identification of a novel G-protein coupled receptor expressed in distinct brain regions and a defined olfactory zone". Receptors & Channels 6 (2): 141–151. 1999. PMID 9932290.
 |  |
