Biology:GNRHR2
Putative gonadotropin-releasing hormone II receptor is a protein that in humans is encoded by the GNRHR2 gene.[1][2]
Function
The receptor for gonadotropin releasing hormone 2 (GnRH2) is encoded by the GnRH2 receptor (GnRHR2) gene. In non-hominoid primates and non-mammalian vertebrates, GnRHR2 encodes a seven-transmembrane G protein-coupled receptor. However, in human, the N-terminus of the predicted protein contains a frameshift and premature stop codon. In human, GnRHR2 transcription occurs but whether the gene produces a functional C-terminal multi-transmembrane protein is currently unresolved. Alternative splice variants have been reported. An untranscribed pseudogene of GnRHR2 is also on chromosome 14.[2]
See also
References
- ↑ "The genes encoding the type II gonadotropin-releasing hormone receptor and the ribonucleoprotein RBM8A in humans overlap in two genomic loci". Genomics 78 (1–2): 15–8. Nov 2001. doi:10.1006/geno.2001.6650. PMID 11707068.
- ↑ 2.0 2.1 "Entrez Gene: GNRHR2 gonadotropin-releasing hormone (type 2) receptor 2". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=114814.
Further reading
- Neill JD (2002). "GnRH and GnRH receptor genes in the human genome". Endocrinology 143 (3): 737–43. doi:10.1210/endo.143.3.8705. PMID 11861490.
- "A novel human GnRH receptor homolog gene: abundant and wide tissue distribution of the antisense transcript". J. Endocrinol. 162 (1): 117–26. 1999. doi:10.1677/joe.0.1620117. PMID 10396028.
- "A gonadotropin-releasing hormone (GnRH) receptor specific for GnRH II in primates". Biochem. Biophys. Res. Commun. 282 (4): 1012–8. 2001. doi:10.1006/bbrc.2001.4678. PMID 11352653.
- "Type II gonadotropin-releasing hormone receptor transcripts in human sperm". Biol. Reprod. 67 (6): 1741–9. 2003. doi:10.1095/biolreprod.101.002808. PMID 12444048.
- "A transcriptionally active human type II gonadotropin-releasing hormone receptor gene homolog overlaps two genes in the antisense orientation on chromosome 1q.12". Endocrinology 144 (2): 423–36. 2003. doi:10.1210/en.2002-220622. PMID 12538601.
- "Inhibition of human type i gonadotropin-releasing hormone receptor (GnRHR) function by expression of a human type II GnRHR gene fragment". Endocrinology 146 (6): 2639–49. 2005. doi:10.1210/en.2005-0133. PMID 15761034.
- "GnRH-II receptor-like antigenicity in human placenta and in cancers of the human reproductive organs". Eur. J. Endocrinol. 153 (4): 605–12. 2005. doi:10.1530/eje.1.02005. PMID 16189182.
- "Comparative genomics of the endocrine systems in humans and chimpanzees with special reference to GNRH2 and UCN2 and their receptors". Genomics 87 (4): 459–62. 2006. doi:10.1016/j.ygeno.2005.11.005. PMID 16406723.
- "Human myometrium and leiomyomas express gonadotropin-releasing hormone 2 and gonadotropin-releasing hormone 2 receptor". Fertil. Steril. 88 (1): 39–46. 2007. doi:10.1016/j.fertnstert.2006.11.098. PMID 17296196. https://zenodo.org/record/1258947.
External links
- "Gonadotrophin-Releasing Hormone Receptors: GnRH2 Receptor". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=3212.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
 |  |
