Biology:GPR176
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Probable G-protein coupled receptor 176 is a protein that in humans is encoded by the GPR176 gene.[1][2]
It is expressed by neurons in the suprachiasmatic nucleus, where it negatively regulates cAMP production in an apparently agonist-independent fashion. Its expression increases at night, indicating it may be involved in circadian rhythm within the brain. Rather than interacting with the canonical Gi protein, it interacts with Gz.[3][4]
References
- ↑ "cDNA cloning of a putative G protein-coupled receptor from brain". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression 1261 (1): 121–125. April 1995. doi:10.1016/0167-4781(95)00002-x. PMID 7893747.
- ↑ "Entrez Gene: GPR176 G protein-coupled receptor 176". https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=11245.
- ↑ "Gpr176 is a Gz-linked orphan G-protein-coupled receptor that sets the pace of circadian behaviour". Nature Communications 7 (1). February 2016. doi:10.1038/ncomms10583. PMID 26882873.
- ↑ "Time-Restricted G-Protein Signaling Pathways via GPR176, Gz, and RGS16 Set the Pace of the Master Circadian Clock in the Suprachiasmatic Nucleus". International Journal of Molecular Sciences 21 (14): 5055. July 2020. doi:10.3390/ijms21145055. PMID 32709014.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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