Biology:Neuropeptide Y receptor Y2

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Neuropeptide Y receptor type 2 (Y2R) is a member of the neuropeptide Y receptor family of G-protein coupled receptors, that in humans is encoded by the NPY2R gene.

Selective ligands

Agonists

• Neuropeptide Y (endogenous agonist, non subtype selective)
• Neuropeptide Y fragment 13-36 (NPY₂ selective agonist)
• Peptide YY
• Peptide YY 3-36 fragment

Antagonists

• BIIE-0246 (CAS# 246146-55-4)
• JNJ 5207787 (CAS# 683746-68-1)
• SF 11 (CAS# 443292-81-7)

See also

• Neuropeptide Y receptor

External links

• "Neuropeptide Y Receptors: Y₂". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2368. 

Further reading

• "Neuropeptide Y receptor subtypes". Life Sciences 56 (13): 1055–64. Feb 1995. doi:10.1016/0024-3205(95)00041-4. PMID 9001438. 
• "Neuropeptide Y receptors as targets for anti-obesity drug development: perspective and current status". European Journal of Pharmacology 440 (2–3): 173–87. Apr 2002. doi:10.1016/S0014-2999(02)01427-9. PMID 12007534. 
• "Cloned human neuropeptide Y receptor couples to two different second messenger systems". Proceedings of the National Academy of Sciences of the United States of America 89 (13): 5794–8. Jul 1992. doi:10.1073/pnas.89.13.5794. PMID 1321422. Bibcode: 1992PNAS...89.5794H. 
• "Expression cloning and pharmacological characterization of a human hippocampal neuropeptide Y/peptide YY Y2 receptor subtype". The Journal of Biological Chemistry 270 (45): 26758–61. Nov 1995. doi:10.1074/jbc.270.45.26758. PMID 7592910. 
• "A pertussis toxin-insensitive calcium influx mediated by neuropeptide Y2 receptors in a human neuroblastoma cell line". The Journal of Biological Chemistry 269 (11): 8226–33. Mar 1994. doi:10.1016/S0021-9258(17)37183-1. PMID 8132547. 
• "Expression cloning of a human brain neuropeptide Y Y2 receptor". Molecular Pharmacology 49 (2): 224–8. Feb 1996. PMID 8632753. 
• "Cloning and functional expression of cDNAs encoding human and rat pancreatic polypeptide receptors". Proceedings of the National Academy of Sciences of the United States of America 93 (10): 4661–5. May 1996. doi:10.1073/pnas.93.10.4661. PMID 8643460. 
• "Characterization of the human type 2 neuropeptide Y receptor gene (NPY2R) and localization to the chromosome 4q region containing the type 1 neuropeptide Y receptor gene". Genomics 38 (3): 392–8. Dec 1996. doi:10.1006/geno.1996.0642. PMID 8975716. 
• "GTPase activating specificity of RGS12 and binding specificity of an alternatively spliced PDZ (PSD-95/Dlg/ZO-1) domain". The Journal of Biological Chemistry 273 (28): 17749–55. Jul 1998. doi:10.1074/jbc.273.28.17749. PMID 9651375. 
• "Regional distribution of neuropeptide Y Y2 receptor messenger RNA in the human post mortem brain". Neuroscience 86 (1): 167–78. Sep 1998. doi:10.1016/S0306-4522(98)00039-6. PMID 9692752. 
• "The peptide YY-preferring receptor mediating inhibition of small intestinal secretion is a peripheral Y(2) receptor: pharmacological evidence and molecular cloning". Molecular Pharmacology 60 (1): 124–34. Jul 2001. doi:10.1124/mol.60.1.124. PMID 11408607. 
• "Neuropeptide Y, Y1, Y2 and Y4 receptors mediate Y agonist responses in isolated human colon mucosa". British Journal of Pharmacology 135 (6): 1505–12. Mar 2002. doi:10.1038/sj.bjp.0704604. PMID 11906964. 
• "Neuropeptide Y Y1 and neuropeptide Y Y2 receptors in human cardiovascular tissues". Peptides 23 (5): 927–34. May 2002. doi:10.1016/S0196-9781(02)00003-7. PMID 12084524. 
• "Functional consequences of neuropeptide Y Y 2 receptor knockout and Y2 antagonism in mouse and human colonic tissues". British Journal of Pharmacology 139 (4): 863–71. Jun 2003. doi:10.1038/sj.bjp.0705298. PMID 12813010. 
• "Studies of the peptide YY and neuropeptide Y2 receptor genes in relation to human obesity and obesity-related traits". Diabetes 53 (9): 2461–6. Sep 2004. doi:10.2337/diabetes.53.9.2461. PMID 15331560. 
• "Structural basis for ligand recognition of the neuropeptide Y Y2 receptor". Nature Communications 12 (1): 737. Feb 2021. doi:10.1038/s41467-021-21030-9. PMID 33531491.