Biology:GPR42
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Putative G-protein coupled receptor 42 (previously termed FFAR1L, FFAR3L, GPR41L, and GPR42P) is a protein that in humans is encoded by the GPR42 gene.[1][2] The human GPR gene is located at the same site as the human FFAR1, FFAR, and FFAR3 genes, i.e., on the long (i.e., "q") arm of chromosome 19 at position 23.33 (notated as 19q23.33). This gene appears to be a segmental duplication of the FFAR3 gene. The human GPR42 gene codes for several proteins with a FFAR3-like structure but their expression in various cell types and tissues as well as their activities and functions have not yet been clearly defined in any scientific publication followed by PubMed as of 2023.[3][4][5][6]
See also
References
- ↑ "A cluster of four novel human G protein-coupled receptor genes occurring in close proximity to CD22 gene on chromosome 19q13.1". Biochem Biophys Res Commun 239 (2): 543–7. Nov 1997. doi:10.1006/bbrc.1997.7513. PMID 9344866.
- ↑ "Entrez Gene: GPR42 G protein-coupled receptor 42". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2866.
- ↑ "The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids". The Journal of Biological Chemistry 278 (13): 11312–9. March 2003. doi:10.1074/jbc.M211609200. PMID 12496283.
- ↑ "Sequence polymorphisms provide a common consensus sequence for GPR41 and GPR42". DNA and Cell Biology 28 (11): 555–60. November 2009. doi:10.1089/dna.2009.0916. PMID 19630535.
- ↑ "Human GPR42 is a transcribed multisite variant that exhibits copy number polymorphism and is functional when heterologously expressed". Scientific Reports 5: 12880. August 2015. doi:10.1038/srep12880. PMID 26260360. Bibcode: 2015NatSR...512880P.
- ↑ "Microbial Short-Chain Fatty Acids and Blood Pressure Regulation". Current Hypertension Reports 19 (4): 25. April 2017. doi:10.1007/s11906-017-0722-5. PMID 28315048.
Further reading
- "A family of fatty acid binding receptors.". DNA Cell Biol. 24 (1): 54–61. 2005. doi:10.1089/dna.2005.24.54. PMID 15684720.
- "The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids.". J. Biol. Chem. 278 (13): 11312–9. 2003. doi:10.1074/jbc.M211609200. PMID 12496283.
- "The DNA sequence and biology of human chromosome 19.". Nature 428 (6982): 529–35. 2004. doi:10.1038/nature02399. PMID 15057824. Bibcode: 2004Natur.428..529G.
External links
- "Free Fatty Acid Receptors: GPR42". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=3058.
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