Biology:Galanin receptor 1

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Galanin receptor 1 (GAL₁) is a G-protein coupled receptor encoded by the GALR1 gene.

Function

The neuropeptide galanin elicits a range of biological effects by interaction with specific G-protein-coupled receptors. Galanin receptors are seven-trans membrane proteins shown to activate a variety of intracellular second-messenger pathways. GALR1 inhibits adenylyl cyclase via a G protein of the GI/GO family. GALR1 is widely expressed in the brain and spinal cord, as well as in peripheral sites such as the small intestine and heart.

See also

• Galanin receptor

Further reading

• "Molecular cloning of a functional human galanin receptor". Proceedings of the National Academy of Sciences of the United States of America 91 (21): 9780–3. Oct 1994. doi:10.1073/pnas.91.21.9780. PMID 7524088. 
• "Identification and biochemical characterization of the human brain galanin receptor". Journal of Molecular Endocrinology 13 (3): 347–56. Dec 1994. doi:10.1677/jme.0.0130347. PMID 7534460. 
• "Delineation of the peptide binding site of the human galanin receptor". The EMBO Journal 15 (2): 236–44. Jan 1996. doi:10.1002/j.1460-2075.1996.tb00354.x. PMID 8617199. 
• "Cloning and quantification of galanin-1 receptor expression by mucosal cells lining the human gastrointestinal tract". Biochemical and Biophysical Research Communications 222 (2): 379–85. May 1996. doi:10.1006/bbrc.1996.0752. PMID 8670213. 
• "Assignment of the gene encoding human galanin receptor (GALNR) to 18q23 by in situ hybridization". Genomics 30 (3): 629–30. Dec 1995. doi:10.1006/geno.1995.1292. PMID 8825658. 
• "Pharmacological characterization and tissue distribution of the human and rat GALR1 receptors". Biochemical and Biophysical Research Communications 233 (3): 823–8. Apr 1997. doi:10.1006/bbrc.1997.6542. PMID 9168941. 
• "Structural organization of the mouse and human GALR1 galanin receptor genes (Galnr and GALNR) and chromosomal localization of the mouse gene". Genomics 45 (3): 496–508. Nov 1997. doi:10.1006/geno.1997.4960. PMID 9367674. 
• "Cloning, chromosomal location, and transcriptional regulation of the human galanin-1 receptor gene (GALN1R)". Biochemical and Biophysical Research Communications 241 (2): 558–64. Dec 1997. doi:10.1006/bbrc.1997.7838. PMID 9425310. 
• "Pharmacological and biochemical characterization of a recombinant human galanin GALR1 receptor: agonist character of chimeric galanin peptides". The Journal of Pharmacology and Experimental Therapeutics 287 (2): 448–56. Nov 1998. PMID 9808667. 
• "Galanin receptor 1 has anti-proliferative effects in oral squamous cell carcinoma". The Journal of Biological Chemistry 280 (24): 22564–71. Jun 2005. doi:10.1074/jbc.M414589200. PMID 15767248. 
• "Human galanin (GAL) and galanin 1 receptor (GALR1) variations are not involved in fat intake and early onset obesity". The Journal of Nutrition 135 (6): 1387–92. Jun 2005. doi:10.1093/jn/135.6.1387. PMID 15930442. 
• "Alcoholism is associated with GALR3 but not two other galanin receptor genes". Genes, Brain and Behavior 6 (5): 473–81. Jul 2007. doi:10.1111/j.1601-183X.2006.00275.x. PMID 17083333. 

External links

• "Galanin Receptors: GAL₁". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2981. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

sr:Galaninski receptor 3