Biology:LPAR2
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Lysophosphatidic acid receptor 2 also known as LPA2 is a protein that in humans is encoded by the LPAR2 gene.[1][2][3] LPA2 is a G protein-coupled receptor that binds the lipid signaling molecule lysophosphatidic acid (LPA).[4]
Function
This gene encodes a member of family I of the G protein-coupled receptors, as well as the EDG family of proteins. This protein functions as a lysophosphatidic acid (LPA) receptor and contributes to Ca2+ mobilization, a critical cellular response to LPA in cells, through association with Gi and Gq proteins.[1]
Interactions
LPAR2 has been shown to interact with TRIP6.[5]
Evolution
Paralogues[6][7]
See also
References
- ↑ 1.0 1.1 "Entrez Gene: LPAR2 Lysophosphatidic acid receptor 2". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9170.
- ↑ "Characterization of a novel subtype of human G protein-coupled receptor for lysophosphatidic acid". J. Biol. Chem. 273 (14): 7906–10. April 1998. doi:10.1074/jbc.273.14.7906. PMID 9525886.
- ↑ "Recombinant human G protein-coupled lysophosphatidic acid receptors mediate intracellular calcium mobilization". Mol. Pharmacol. 54 (5): 881–8. November 1998. doi:10.1124/mol.54.5.881. PMID 9804623.
- ↑ "LPA Receptors: Subtypes and Biological Actions". Annual Review of Pharmacology and Toxicology 50 (1): 157–186. January 2010. doi:10.1146/annurev.pharmtox.010909.105753. PMID 20055701.
- ↑ Xu, Jun; Lai Yun-Ju; Lin Weei-Chin; Lin Fang-Tsyr (March 2004). "TRIP6 enhances lysophosphatidic acid-induced cell migration by interacting with the lysophosphatidic acid 2 receptor". J. Biol. Chem. (United States) 279 (11): 10459–68. doi:10.1074/jbc.M311891200. ISSN 0021-9258. PMID 14688263.
- ↑ "GeneCards®: The Human Gene Database". https://www.genecards.org/cgi-bin/carddisp.pl?gene=LPAR2&keywords=LPAR2#paralogs.
- ↑ "Ensembl Genome Browser". https://useast.ensembl.org/Homo_sapiens/Gene/Compara_Paralog?db=core;g=ENSG00000064547;r=19:19623655-19628930.
Further reading
- Spiegel S (2000). "Sphingosine 1-phosphate: a ligand for the EDG-1 family of G-protein-coupled receptors.". Ann. N. Y. Acad. Sci. 905 (1): 54–60. doi:10.1111/j.1749-6632.2000.tb06537.x. PMID 10818441. Bibcode: 2000NYASA.905...54S.
- "Lysophosphatidic acid receptors.". Mol. Pharmacol. 58 (6): 1188–96. 2001. doi:10.1124/mol.58.6.1188. PMID 11093753.
- "Distinctive expression and functions of the type 4 endothelial differentiation gene-encoded G protein-coupled receptor for lysophosphatidic acid in ovarian cancer.". Cancer Res. 59 (20): 5370–5. 1999. PMID 10537322.
- "Genomic characterization of the lysophosphatidic acid receptor gene, lp(A2)/Edg4, and identification of a frameshift mutation in a previously characterized cDNA.". Genomics 64 (2): 155–69. 2000. doi:10.1006/geno.2000.6122. PMID 10729222.
- "Lysophosphatidic acid (LPA) receptors of the EDG family are differentially activated by LPA species. Structure-activity relationship of cloned LPA receptors.". FEBS Lett. 478 (1–2): 159–65. 2000. doi:10.1016/S0014-5793(00)01827-5. PMID 10922489.
- "Lysophosphatidic acid-induced Ca2+ mobilization requires intracellular sphingosine 1-phosphate production. Potential involvement of endogenous EDG-4 receptors.". J. Biol. Chem. 275 (49): 38532–9. 2001. doi:10.1074/jbc.M006631200. PMID 10954727.
- "Altered expression and functional profile of lysophosphatidic acid receptors in mitogen-activated human blood T lymphocytes.". FASEB J. 14 (15): 2387–9. 2001. doi:10.1096/fj.00-0492fje. PMID 11024010.
- "Lysophosphatidic acid (LPA) receptors are activated differentially by biological fluids: possible role of LPA-binding proteins in activation of LPA receptors.". FEBS Lett. 523 (1–3): 187–92. 2002. doi:10.1016/S0014-5793(02)02976-9. PMID 12123830.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Expression of lysophosphatidic acid receptors and vascular endothelial growth factor mediating lysophosphatidic acid in the development of human ovarian cancer.". Cancer Lett. 192 (2): 161–9. 2003. doi:10.1016/S0304-3835(02)00713-9. PMID 12668280.
- "Dual mechanisms for lysophosphatidic acid stimulation of human ovarian carcinoma cells.". J. Natl. Cancer Inst. 95 (10): 733–40. 2003. doi:10.1093/jnci/95.10.733. PMID 12759391.
- "TRIP6 enhances lysophosphatidic acid-induced cell migration by interacting with the lysophosphatidic acid 2 receptor.". J. Biol. Chem. 279 (11): 10459–68. 2004. doi:10.1074/jbc.M311891200. PMID 14688263.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
- "The DNA sequence and biology of human chromosome 19.". Nature 428 (6982): 529–35. 2004. doi:10.1038/nature02399. PMID 15057824. Bibcode: 2004Natur.428..529G.
- "NHERF2 specifically interacts with LPA2 receptor and defines the specificity and efficiency of receptor-mediated phospholipase C-beta3 activation.". Mol. Cell. Biol. 24 (11): 5069–79. 2004. doi:10.1128/MCB.24.11.5069-5079.2004. PMID 15143197.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
External links
- "Lysophospholipid Receptors: LPA2". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2991.
- Lysophospholipid+receptors at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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