Biology:P2RY4
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
P2Y purinoceptor 4 is a protein that in humans is encoded by the P2RY4 gene.[1][2]
The product of this gene, P2Y4, belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is responsive to uridine nucleotides, partially responsive to ATP, and not responsive to ADP.[2]
See also
References
- ↑ "Cloning and functional expression of a human uridine nucleotide receptor". J Biol Chem 270 (52): 30849–52. Feb 1996. doi:10.1074/jbc.270.52.30849. PMID 8537336.
- ↑ 2.0 2.1 "Entrez Gene: P2RY4 pyrimidinergic receptor P2Y, G-protein coupled, 4". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5030.
Further reading
- "Cloning, expression, and chromosomal localization of the human uridine nucleotide receptor gene.". J. Biol. Chem. 270 (52): 30845–8. 1996. doi:10.1074/jbc.270.52.30845. PMID 8537335.
- "Molecular cloning and characterization of a novel orphan receptor (P2P) expressed in human pancreas that shows high structural homology to the P2U purinoceptor.". FEBS Lett. 384 (3): 260–4. 1996. doi:10.1016/0014-5793(96)00321-3. PMID 8617367.
- "Uridine nucleotide selectivity of three phospholipase C-activating P2 receptors: identification of a UDP-selective, a UTP-selective, and an ATP- and UTP-specific receptor.". Mol. Pharmacol. 50 (2): 224–9. 1996. PMID 8700127.
- "Cloning of P2Y6 cDNAs and identification of a pseudogene: comparison of P2Y receptor subtype expression in bone and brain tissues.". Biochem. Biophys. Res. Commun. 237 (2): 297–302. 1997. doi:10.1006/bbrc.1997.7135. PMID 9268704.
- "Distribution of P2Y receptor subtypes on haematopoietic cells.". Br. J. Pharmacol. 123 (5): 789–94. 1998. doi:10.1038/sj.bjp.0701665. PMID 9535005.
- "Differential regulation of the uridine nucleotide-activated P2Y4 and P2Y6 receptors. SER-333 and SER-334 in the carboxyl terminus are involved in agonist-dependent phosphorylation desensitization and internalization of the P2Y4 receptor.". J. Biol. Chem. 276 (15): 11939–48. 2001. doi:10.1074/jbc.M009909200. PMID 11114308.
- "Molecular cloning and characterization of the mouse P2Y4 nucleotide receptor.". Eur. J. Pharmacol. 416 (3): 197–202. 2001. doi:10.1016/S0014-2999(01)00875-5. PMID 11290369.
- "Expression pattern of human P2Y receptor subtypes: a quantitative reverse transcription-polymerase chain reaction study.". Biochim. Biophys. Acta 1521 (1–3): 107–19. 2001. doi:10.1016/S0167-4781(01)00291-3. PMID 11690642.
- "Nucleotides induce chemotaxis and actin polymerization in immature but not mature human dendritic cells via activation of pertussis toxin-sensitive P2y receptors.". Blood 100 (3): 925–32. 2002. doi:10.1182/blood.V100.3.925. PMID 12130504.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Human keratinocytes express multiple P2Y-receptors: evidence for functional P2Y1, P2Y2, and P2Y4 receptors.". J. Invest. Dermatol. 120 (3): 440–7. 2003. doi:10.1046/j.1523-1747.2003.12050.x. PMID 12603858.
- "Tumor necrosis factor alpha-induced apoptosis in astrocytes is prevented by the activation of P2Y6, but not P2Y4 nucleotide receptors.". Biochem. Pharmacol. 65 (6): 923–31. 2003. doi:10.1016/S0006-2952(02)01614-3. PMID 12623123.
- "Agonist versus antagonist action of ATP at the P2Y4 receptor is determined by the second extracellular loop.". J. Biol. Chem. 279 (12): 11456–64. 2004. doi:10.1074/jbc.M301734200. PMID 14670966.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "The metabotropic P2Y4 receptor participates in the commitment to differentiation and cell death of human neuroblastoma SH-SY5Y cells.". Neurobiol. Dis. 18 (1): 100–9. 2005. doi:10.1016/j.nbd.2004.09.001. PMID 15649700.
- "The DNA sequence of the human X chromosome.". Nature 434 (7031): 325–37. 2005. doi:10.1038/nature03440. PMID 15772651. Bibcode: 2005Natur.434..325R.
External links
- "P2Y Receptors: P2Y4". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2396.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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