Biology:Parathyroid hormone 2 receptor

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Parathyroid hormone 2 receptor is a protein that in humans is encoded by the PTH2R gene.

Function

The protein encoded by this gene is a member of the G protein-coupled receptor family 2. This protein is a receptor for parathyroid hormone (PTH). This receptor is more selective in ligand recognition and has a more specific tissue distribution compared to parathyroid hormone 1 receptor (PTH1R). It is activated by PTH but not by parathyroid hormone-like hormone (PTHLH) and is particularly abundant in the brain and pancreas.

The molecular interaction of the PTH2 receptor with the peptide TIP39 has been characterized in full 3D molecular detail, identifying among other residues Tyr-318 in transmembrane helix 5 as a key residue for high affinity binding.

See also

• Parathyroid hormone receptor

Further reading

• "Identification and functional expression of a receptor selectively recognizing parathyroid hormone, the PTH2 receptor.". J. Biol. Chem. 270 (26): 15455–8. 1995. doi:10.1074/jbc.270.26.15455. PMID 7797535. 
• "Assignment of the human PTH2 receptor gene (PTHR2) to chromosome 2q33 by fluorescence in situ hybridization.". Genomics 37 (1): 140–1. 1997. doi:10.1006/geno.1996.0532. PMID 8921382. 
• "Multiple regions of ligand discrimination revealed by analysis of chimeric parathyroid hormone 2 (PTH2) and PTH/PTH-related peptide (PTHrP) receptors.". Mol. Endocrinol. 12 (2): 193–206. 1998. doi:10.1210/mend.12.2.0063. PMID 9482662. 
• "Molecular determinants of tuberoinfundibular peptide of 39 residues (TIP39) selectivity for the parathyroid hormone-2 (PTH2) receptor. N-terminal truncation of TIP39 reverses PTH2 receptor/PTH1 receptor binding selectivity.". J. Biol. Chem. 275 (35): 27274–83. 2000. doi:10.1074/jbc.M003910200. PMID 10854439. 
• "Identification and characterization of the murine and human gene encoding the tuberoinfundibular peptide of 39 residues.". Endocrinology 143 (3): 1047–57. 2002. doi:10.1210/endo.143.3.8698. PMID 11861531. 
• "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M. 
• "The parathyroid hormone-2 receptor is expressed on human leukocytes and down-regulated in hyperparathyroidism.". Clin. Nephrol. 59 (6): 429–35. 2003. doi:10.5414/CNP59429. PMID 12834174. 
• "Agonist-specific regulation of parathyroid hormone (PTH) receptor type 2 activity: structural and functional analysis of PTH- and tuberoinfundibular peptide (TIP) 39-stimulated desensitization and internalization.". Mol. Endocrinol. 18 (6): 1486–98. 2004. doi:10.1210/me.2003-0487. PMID 14988434. 
• "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334. 
• "Calmodulin interacts with the cytoplasmic tails of the parathyroid hormone 1 receptor and a sub-set of class b G-protein coupled receptors.". FEBS Lett. 579 (3): 803–7. 2005. doi:10.1016/j.febslet.2004.12.056. PMID 15670850. 
• "High affinity binding of the peptide agonist TIP-39 to the Parathyroid hormone 2 (PTH2) receptor requires the hydroxyl group of Tyr-318 on transmembrane helix 5.". Biochemical Pharmacology 127: 71–81. 2017. doi:10.1016/j.bcp.2016.12.013. PMID 28012961. 

External links

• "Parathyroid Hormone Receptors: PTH2". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2970. 
• Receptor,+Parathyroid+Hormone,+Type+2 at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.