Biology:GPR128

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Short description: Protein-coding gene in the species Homo sapiens


A representation of the 3D structure of the protein myoglobin showing turquoise α-helices.
Generic protein structure example

G protein-coupled receptor 128 is a protein encoded by the ADGRG7 gene.[1][2][3] GPR128 is a member of the adhesion GPCR family.[4][5] Adhesion GPCRs are characterized by an extended extracellular region often possessing N-terminal protein modules that is linked to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.[6]

GPR128 is specifically expressed in human liver as well as in mouse bone marrow and intestinal tissues.[7]

Function

Ni et al. showed that Gpr128 deletion in mice causes reduced body weight and induced intestinal contraction frequency.[8]

Clinical significance

A 111-kb copy number gain with breakpoints within the TRK-fused gene (a target of translocations in lymphoma and thyroid tumors) and GPR128 has been identified in the genome of patients with atypical myeloproliferative neoplasms.[9] Notably, the fused gene was also detected in few healthy individuals.

References

  1. ↑ "Entrez Gene: GPR128 G protein-coupled receptor 128". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84873. 
  2. ↑ "Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions". FEBS Letters 531 (3): 407–14. November 2002. doi:10.1016/S0014-5793(02)03574-3. PMID 12435584. 
  3. ↑ Hamann, J; Aust, G; Araç, D; Engel, FB; Formstone, C; Fredriksson, R; Hall, RA; Harty, BL et al. (April 2015). "International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors.". Pharmacological Reviews 67 (2): 338–67. doi:10.1124/pr.114.009647. PMID 25713288. 
  4. ↑ Stacey M, Yona S (2011). Adhesion-GPCRs: Structure to Function (Advances in Experimental Medicine and Biology). Berlin: Springer. ISBN 978-1-4419-7912-4. 
  5. ↑ Langenhan, T; Aust, G; Hamann, J (21 May 2013). "Sticky signaling--adhesion class G protein-coupled receptors take the stage.". Science Signaling 6 (276): re3. doi:10.1126/scisignal.2003825. PMID 23695165. 
  6. ↑ "A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis". The EMBO Journal 31 (6): 1364–78. March 2012. doi:10.1038/emboj.2012.26. PMID 22333914. 
  7. ↑ "International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors". Pharmacological Reviews 67 (2): 338–67. April 2015. doi:10.1124/pr.114.009647. PMID 25713288. 
  8. ↑ "Deletion of Gpr128 results in weight loss and increased intestinal contraction frequency". World Journal of Gastroenterology 20 (2): 498–508. Jan 2014. doi:10.3748/wjg.v20.i2.498. PMID 24574718. 
  9. ↑ "TFG, a target of chromosome translocations in lymphoma and soft tissue tumors, fuses to GPR128 in healthy individuals". Haematologica 95 (1): 20–6. Jan 2010. doi:10.3324/haematol.2009.011536. PMID 19797732. 

External links



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