Biology:TAS2R9
 Generic protein structure example |
Taste receptor type 2 member 9 is a protein that in humans is encoded by the TAS2R9 gene.[1][2][3]
Function
This gene product belongs to the family of candidate taste receptors that are members of the G-protein-coupled receptor superfamily. These proteins are specifically expressed in the taste receptor cells of the tongue and palate epithelia. They are organized in the genome in clusters and are genetically linked to loci that influence bitter perception in mice and humans. In functional expression studies, they respond to bitter tastants. This gene maps to the taste receptor gene cluster on chromosome 12p13.[3]
Polymorphisms in this gene have been associated with the perceived bitterness of sweetener acesulfame potassium.[4]
See also
References
- ↑ "A novel family of mammalian taste receptors". Cell 100 (6): 693–702. Apr 2000. doi:10.1016/S0092-8674(00)80705-9. PMID 10761934.
- ↑ "A family of candidate taste receptors in human and mouse". Nature 404 (6778): 601–4. Apr 2000. doi:10.1038/35007072. PMID 10766242.
- ↑ 3.0 3.1 "Entrez Gene: TAS2R9 taste receptor, type 2, member 9". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=50835.
- ↑ "Bitterness of the non-nutritive sweetener acesulfame potassium varies with polymorphisms in TAS2R9 and TAS2R31". Chem. Senses 38 (5): 379–89. 2013. doi:10.1093/chemse/bjt017. PMID 23599216.
Further reading
- Kinnamon SC (2000). "A plethora of taste receptors". Neuron 25 (3): 507–10. doi:10.1016/S0896-6273(00)81054-5. PMID 10774719.
- Margolskee RF (2002). "Molecular mechanisms of bitter and sweet taste transduction". J. Biol. Chem. 277 (1): 1–4. doi:10.1074/jbc.R100054200. PMID 11696554.
- "Receptors for bitter and sweet taste". Curr. Opin. Neurobiol. 12 (4): 366–71. 2002. doi:10.1016/S0959-4388(02)00345-8. PMID 12139982.
- "T2Rs function as bitter taste receptors". Cell 100 (6): 703–11. 2000. doi:10.1016/S0092-8674(00)80706-0. PMID 10761935.
- "Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways". Cell 112 (3): 293–301. 2003. doi:10.1016/S0092-8674(03)00071-0. PMID 12581520.
- "Evolution of bitter taste receptors in humans and apes". Mol. Biol. Evol. 22 (3): 432–6. 2005. doi:10.1093/molbev/msi027. PMID 15496549.
- "Lineage-Specific Loss of Function of Bitter Taste Receptor Genes in Humans and Nonhuman Primates". Genetics 170 (1): 313–26. 2006. doi:10.1534/genetics.104.037523. PMID 15744053.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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