Biology:TAAR5

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Short description: Protein-coding gene in the species Homo sapiens


A representation of the 3D structure of the protein myoglobin showing turquoise α-helices.
Generic protein structure example

Trace amine-associated receptor 5 is a protein that in humans is encoded by the TAAR5 gene.[1][2][3] In vertebrates, TAAR5 is expressed in the olfactory epithelium.[4]

Human TAAR5 (hTAAR5) is a functional trace amine-associated receptor which acts as an olfactory receptor for tertiary amines.[4][5] Trimethylamine and N,N-dimethylethylamine are full agonists of hTAAR5.[5][6][7] The amber-woody fragrance timberol antagonizes this activity of trimethylamine.[8] 3-Iodothyronamine is an inverse agonist of hTAAR5.[9][10] Recent studies highlighted the significant role of TAAR5 in the central nervous system and periphery. Beta-galactosidase mapping of TAAR5 expression showed its localization not only in the glomeruli but also in deeper layers of olfactory bulb projecting to the limbic brain olfactory circuitry. Moreover, TAAR5 knockout mice show increased adult neurogenesis and elevated number of dopamine neurons. Also, it was observed statistically significant changes in osmotic erythrocyte fragility in TAAR5-KO mice.[11]

Mutations in the TAAR5 gene were found to affect human olfaction. Icelanders with a mutation in the gene were less likely to describe fish smell containing trimethylamine as unpleasant, and described licorice odor and cinnamon odor more intensely.[12]

See also

References

  1. ↑ "Cloning of a putative human neurotransmitter receptor expressed in skeletal muscle and brain". Biochem Biophys Res Commun 242 (3): 575–8. Mar 1998. doi:10.1006/bbrc.1997.7591. PMID 9464258. 
  2. ↑ "Trace amine-associated receptors form structurally and functionally distinct subfamilies of novel G protein-coupled receptors". Genomics 85 (3): 372–85. Feb 2005. doi:10.1016/j.ygeno.2004.11.010. PMID 15718104. 
  3. ↑ "Entrez Gene: TAAR5 trace amine associated receptor 5". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9038. 
  4. ↑ 4.0 4.1 "Trace amine-associated receptors: ligands, neural circuits, and behaviors". Curr. Opin. Neurobiol. 34: 1–7. 2015. doi:10.1016/j.conb.2015.01.001. PMID 25616211. "All TAARs except TAAR1 function as olfactory receptors, based on studies in rodent, primate, and fish [4,7,10]. TAAR expression is highly enriched in the olfactory system by quantitative PCR (qPCR) analysis, with little or no expression in other tissues examined [4].". 
  5. ↑ 5.0 5.1 "Microbial metabolism of dietary components to bioactive metabolites: opportunities for new therapeutic interventions". Genome Med 8 (1): 46. April 2016. doi:10.1186/s13073-016-0296-x. PMID 27102537. 
    Table 2: Microbial metabolites: their synthesis, mechanisms of action, and effects on health and disease
    Figure 1: Molecular mechanisms of action of indole and its metabolites on host physiology and disease
  6. ↑ "Human trace amine-associated receptor TAAR5 can be activated by trimethylamine". PLOS ONE 8 (2): e54950. 2013. doi:10.1371/journal.pone.0054950. PMID 23393561. Bibcode: 2013PLoSO...854950W. 
  7. ↑ "Ultrasensitive detection of amines by a trace amine-associated receptor". J. Neurosci. 33 (7): 3228–39. February 2013. doi:10.1523/JNEUROSCI.4299-12.2013. PMID 23407976. "We show that [human TAAR5] responds to the tertiary amine N,N-dimethylethylamine and to a lesser extent to trimethylamine, a structurally related agonist for mouse and rat TAAR5 (Liberles and Buck, 2006; Staubert et al., 2010; Ferrero et al., 2012).". 
  8. ↑ "Timberol® Inhibits TAAR5-Mediated Responses to Trimethylamine and Influences the Olfactory Threshold in Humans". PLOS ONE 10 (12): e0144704. 2015. doi:10.1371/journal.pone.0144704. PMID 26684881. Bibcode: 2015PLoSO..1044704W. "While mice produce gender-specific amounts of urinary TMA levels and were attracted by TMA, this odor is repellent to rats and aversive to humans [19], indicating that there must be species-specific functions. ... Furthermore, a homozygous knockout of murine TAAR5 abolished the attraction behavior to TMA [19]. Thus, it is concluded that TAAR5 itself is sufficient to mediate a behavioral response at least in mice. ... Whether the TAAR5 activation by TMA elicits specific behavioral output like avoidance behavior in humans still needs to be examined.". 
  9. ↑ "Inverse agonistic action of 3-iodothyronamine at the human trace amine-associated receptor 5". PLOS ONE 10 (2): e0117774. 2015. doi:10.1371/journal.pone.0117774. PMID 25706283. Bibcode: 2015PLoSO..1017774D. 
  10. ↑ "The emerging roles of human trace amines and human trace amine-associated receptors (hTAARs) in central nervous system". Biomed. Pharmacother. 83: 439–449. October 2016. doi:10.1016/j.biopha.2016.07.002. PMID 27424325. 
  11. ↑ "Minor Changes in Erythrocyte Osmotic Fragility in Trace Amine-Associated Receptor 5 (TAAR5) Knockout Mice". International Journal of Molecular Sciences 22 (14): 7307. July 2021. doi:10.3390/ijms22147307. PMID 34298937. 
  12. ↑ Gisladottir, Rosa S.; Ivarsdottir, Erna V.; Helgason, Agnar; Jonsson, Lina; Hannesdottir, Nanna K.; Rutsdottir, Gudrun; Arnadottir, Gudny A.; Skuladottir, Astros et al. (December 2020). "Sequence Variants in TAAR5 and Other Loci Affect Human Odor Perception and Naming". Current Biology 30 (23): 4643–4653.e3. doi:10.1016/j.cub.2020.09.012. ISSN 0960-9822. PMID 33035477. https://doi.org/10.1016/j.cub.2020.09.012. 

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.




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