Biology:Relaxin receptor

Short description: InterPro Family

relaxin/insulin-like family peptide receptor 1
Identifiers
Symbol	RXFP1
Alt. symbols	LGR7
NCBI gene	59350
HGNC	19718
OMIM	606654
RefSeq	NM_021634
UniProt	Q9HBX9
Other data
Locus	Chr. 4 q31.3

relaxin/insulin-like family peptide receptor 2
Identifiers
Symbol	RXFP2
Alt. symbols	LGR8, GREAT, GPR106, INSL3R
NCBI gene	122042
HGNC	17318
OMIM	606655
RefSeq	NM_130806
UniProt	Q8WXD0
Other data
Locus	Chr. 13 q12.3

relaxin/insulin-like family peptide receptor 3
Identifiers
Symbol	RXFP3
Alt. symbols	RLN3R1, SALPR, GPCR135
NCBI gene	51289
HGNC	24883
OMIM	609445
RefSeq	NM_016568
UniProt	Q9NSD7
Other data
Locus	Chr. 5 p15.1-p14

relaxin/insulin-like family peptide receptor 4
Identifiers
Symbol	RXFP4
Alt. symbols	GPR100, GPCR142, RLN3R2
NCBI gene	339403
HGNC	14666
OMIM	609043
RefSeq	NM_181885
UniProt	Q8TDU9
Other data
Locus	Chr. 1 q22

The relaxin receptors are a subclass of four closely related G protein-coupled receptors (GPCR) that bind relaxin peptide hormones.

Below is list of human relaxin receptors, their endogenous peptide hormones, and what downstream enzymes are activated or inhibited by the receptor.

receptor/gene	ligands	activates	inhibits
RXFP1	relaxin 1, relaxin 2, relaxin 3	adenylate cyclase, protein kinase A, protein kinase C, phosphatidylinositol 3-kinase, extracellular signal-regulated kinases (Erk1/2)
RXFP2	relaxin 1, relaxin 2, insulin-like 3	adenylate cyclase
RXFP3	relaxin 3	Erk1/2 signaling	adenylate cyclase
RXFP4	relaxin 3, insulin-like 3		adenylate cyclase

See also

• Relaxin family peptide hormones
• Insulin/IGF/Relaxin family
• Relaxin/insulin-like family peptide receptor 1

External links

• "Relaxin Family Peptide Receptors: Motilin". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/GPCR/ChapterMenuForward?chapterID=1352. 
• relaxin+receptors at the US National Library of Medicine Medical Subject Headings (MeSH)