Biology:EGF module-containing mucin-like hormone receptor
From HandWiki
Short description: G protein-coupled receptor
| egf-like module containing, mucin-like, hormone receptor-like 1 | |
|---|---|
| Identifiers | |
| Symbol | EMR1 |
| Alt. symbols | TM7LN3 |
| IUPHAR | 182 |
| NCBI gene | 2015 |
| HGNC | 3336 |
| OMIM | 600493 |
| RefSeq | NM_001974 |
| UniProt | Q14246 |
| Other data | |
| Locus | Chr. 19 p13.3 |
| egf-like module containing, mucin-like, hormone receptor-like 2 | |
|---|---|
| Identifiers | |
| Symbol | EMR2 |
| IUPHAR | 183 |
| NCBI gene | 30817 |
| HGNC | 3337 |
| OMIM | 606100 |
| RefSeq | NM_152916 |
| UniProt | Q9UHX3 |
| Other data | |
| Locus | Chr. 19 p13.1 |
| egf-like module containing, mucin-like, hormone receptor-like 3 | |
|---|---|
| Identifiers | |
| Symbol | EMR3 |
| IUPHAR | 184 |
| NCBI gene | 84658 |
| HGNC | 23647 |
| OMIM | 606101 |
| RefSeq | NM_032571 |
| UniProt | Q9BY15 |
| Other data | |
| Locus | Chr. 19 p13.1 |
| egf-like module containing, mucin-like, hormone receptor-like 4 pseudogene | |
|---|---|
| Identifiers | |
| Symbol | EMR4P |
| Alt. symbols | GPR127 |
| NCBI gene | 326342 |
| HGNC | 19240 |
| RefSeq | XM_940358 |
| UniProt | Q86SQ3 |
| Other data | |
| Locus | Chr. 19 p13.3 |
The EGF module-containing Mucin-like hormone Receptors (EMRs) are closely related subgroup of G protein-coupled receptors (GPCRs). These receptors have a unique hybrid structure in which an extracellular epidermal growth factor (EGF)-like domain is fused to a GPCR domain through a mucin-like stalk.[1][2][3][4] There are four variants of EMR labeled 1–4, each encoded by a separate gene. These receptors are predominantly expressed in cells of the immune system and bind ligands such as CD55.[5]
References
- ↑ "EMR1, an unusual member in the family of hormone receptors with seven transmembrane segments". Genomics 26 (2): 334–44. 1995. doi:10.1016/0888-7543(95)80218-B. PMID 7601460.
- ↑ "Human EMR2, a novel EGF-TM7 molecule on chromosome 19p13.1, is closely related to CD97". Genomics 67 (2): 188–200. 2000. doi:10.1006/geno.2000.6238. PMID 10903844.
- ↑ "Human epidermal growth factor (EGF) module-containing mucin-like hormone receptor 3 is a new member of the EGF-TM7 family that recognizes a ligand on human macrophages and activated neutrophils". J. Biol. Chem. 276 (22): 18863–70. 2001. doi:10.1074/jbc.M101147200. PMID 11279179.
- ↑ "Gene structure and transcript analysis of the human and mouse EGF-TM7 molecule, FIRE". DNA Seq. 17 (1): 8–14. 2006. doi:10.1080/10425170500355737. PMID 16753812.
- ↑ "The EGF-TM7 family: a postgenomic view". Immunogenetics 55 (10): 655–66. 2004. doi:10.1007/s00251-003-0625-2. PMID 14647991.
External links
- EMR1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
- EMR2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
- EMR3+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
- EMR4+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
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