Biology:EGF module-containing mucin-like hormone receptor

From HandWiki
Short description: G protein-coupled receptor
egf-like module containing, mucin-like, hormone receptor-like 4 pseudogene
Identifiers
SymbolEMR4P
Alt. symbolsGPR127
NCBI gene326342
HGNC19240
RefSeqXM_940358
UniProtQ86SQ3
Other data
LocusChr. 19 p13.3

The EGF module-containing Mucin-like hormone Receptors (EMRs) are closely related subgroup of G protein-coupled receptors (GPCRs). These receptors have a unique hybrid structure in which an extracellular epidermal growth factor (EGF)-like domain is fused to a GPCR domain through a mucin-like stalk.[1][2][3][4] There are four variants of EMR labeled 1–4, each encoded by a separate gene. These receptors are predominantly expressed in cells of the immune system and bind ligands such as CD55.[5]

References

  1. "EMR1, an unusual member in the family of hormone receptors with seven transmembrane segments". Genomics 26 (2): 334–44. 1995. doi:10.1016/0888-7543(95)80218-B. PMID 7601460. 
  2. "Human EMR2, a novel EGF-TM7 molecule on chromosome 19p13.1, is closely related to CD97". Genomics 67 (2): 188–200. 2000. doi:10.1006/geno.2000.6238. PMID 10903844. 
  3. "Human epidermal growth factor (EGF) module-containing mucin-like hormone receptor 3 is a new member of the EGF-TM7 family that recognizes a ligand on human macrophages and activated neutrophils". J. Biol. Chem. 276 (22): 18863–70. 2001. doi:10.1074/jbc.M101147200. PMID 11279179. 
  4. "Gene structure and transcript analysis of the human and mouse EGF-TM7 molecule, FIRE". DNA Seq. 17 (1): 8–14. 2006. doi:10.1080/10425170500355737. PMID 16753812. 
  5. "The EGF-TM7 family: a postgenomic view". Immunogenetics 55 (10): 655–66. 2004. doi:10.1007/s00251-003-0625-2. PMID 14647991. 

External links