Biology:GPRC5D
 Generic protein structure example |
G-protein coupled receptor family C group 5 member D is a protein that in humans is encoded by the GPRC5D gene.[1] GPRC5D is a class C orphan G protein-coupled receptor predominantly expressed in multiple myeloma cells and hard keratinized tissues, with low expression in normal human tissues, rendering it an appealing target for multiple myeloma cells.[2][3][4]
Structure
Structural analysis of the complex between GPRC5D and talquetamab, a bispecific antibody for the treatment of multiple myeloma, has revealed that GPRC5D exists as a dimer. GPRC5D forms a symmetric dimer via TM4 and TM4/TM5 interactions. The study further demonstrated that only one talquetamab molecule can bind to the dimeric form of GPRC5D. Talquetamab Fab recognizes ECLs and TM3/5/7 of one GPRC5D protomer via six CDRs.[5]
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Function
The protein encoded by this gene is a member of the G protein-coupled receptor family; however, the specific function of this gene has not yet been determined.[1]
See also
References
- ↑ 1.0 1.1 "Entrez Gene: GPRC5D G protein-coupled receptor, family C, group 5, member D". https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=55507.
- ↑ "The RAIG family member, GPRC5D, is associated with hard-keratinized structures". J. Invest. Dermatol..
- ↑ "GPRC5D is a target for the immunotherapy of multiple myeloma with rationally designed CAR T cells". Science Translational Medicine 11 (485). March 2019. doi:10.1126/scitranslmed.aau7746. PMID 30918115.
- ↑ "Preclinical activity and determinants of response of the GPRC5DxCD3 bispecific antibody talquetamab in multiple myeloma". Blood Advances 5 (8): 2196–2215. April 2021. doi:10.1182/bloodadvances.2020003805. PMID 33890981.
- ↑ "Structural Basis for the Recognition of GPRC5D by Talquetamab, a Bispecific Antibody for Multiple Myeloma". Journal of Molecular Biology 436 (20). August 2024. doi:10.1016/j.jmb.2024.168748. PMID 39181182.
Further reading
- "Cloning and characterization of a human orphan family C G-protein coupled receptor GPRC5D". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression 1518 (3): 237–248. April 2001. doi:10.1016/s0167-4781(01)00197-x. PMID 11311935.
- "Identification of G protein-coupled receptor genes from the human genome sequence". FEBS Letters 520 (1–3): 97–101. June 2002. doi:10.1016/S0014-5793(02)02775-8. PMID 12044878. Bibcode: 2002FEBSL.520...97T.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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