Biology:P2RY14

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

P2Y purinoceptor 14 is a protein that in humans is encoded by the P2RY14 gene.

The product of this gene, P2Y₁₄ belongs to the family of G-protein coupled receptors, which contains several receptor subtypes with different pharmacological selectivity for various adenosine and uridine nucleotides. This receptor is a P2Y purinergic receptor for UDP-glucose and other UDP-sugars coupled to G-proteins. It has been implicated in extending the known immune system functions of P2Y receptors by participating in the regulation of the stem cell compartment, and it may also play a role in neuroimmune function. Two transcript variants encoding the same protein have been identified for this gene.

See also

• P2Y receptor

Further reading

• "C5A anaphylatoxin and its seven transmembrane-segment receptor". Annu. Rev. Immunol. 12: 775–808. 1994. doi:10.1146/annurev.iy.12.040194.004015. PMID 8011297. 
• Müller CE (2003). "P2-pyrimidinergic receptors and their ligands". Curr. Pharm. Des. 8 (26): 2353–2369. doi:10.2174/1381612023392937. PMID 12369950. 
• "Characterization of the UDP-glucose receptor (re-named here the P2Y14 receptor) adds diversity to the P2Y receptor family". Trends Pharmacol. Sci. 24 (2): 52–55. 2003. doi:10.1016/S0165-6147(02)00038-X. PMID 12559763. 
• von Kügelgen I (2006). "Pharmacological profiles of cloned mammalian P2Y-receptor subtypes". Pharmacol. Ther. 110 (3): 415–432. doi:10.1016/j.pharmthera.2005.08.014. PMID 16257449. 
• "P2 receptors activated by uracil nucleotides--an update". Curr. Med. Chem. 13 (3): 289–312. 2006. doi:10.2174/092986706775476052. PMID 16475938. 
• "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1". DNA Res. 1 (1): 27–35. 1995. doi:10.1093/dnares/1.1.27. PMID 7584026. 
• "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement)". DNA Res. 1 (1): 47–56. 1995. doi:10.1093/dnares/1.1.47. PMID 7584028. 
• "The isolation and characterization of a novel G protein-coupled receptor regulated by immunologic challenge". Brain Res. 764 (1–2): 141–148. 1997. doi:10.1016/S0006-8993(97)00438-1. PMID 9295203. 
• "A sequence-ready map of the Usher syndrome type III critical region on chromosome 3q". Genomics 63 (3): 409–416. 2000. doi:10.1006/geno.1999.6096. PMID 10704288. 
• "A G protein-coupled receptor for UDP-glucose". J. Biol. Chem. 275 (15): 10767–10771. 2000. doi:10.1074/jbc.275.15.10767. PMID 10753868. 
• "An expressed sequence tag (EST) data mining strategy succeeding in the discovery of new G-protein coupled receptors". J. Mol. Biol. 307 (3): 799–813. 2001. doi:10.1006/jmbi.2001.4520. PMID 11273702. 
• "Mutations in a Novel Gene with Transmembrane Domains Underlie Usher Syndrome Type 3". Am. J. Hum. Genet. 69 (4): 673–684. 2001. doi:10.1086/323610. PMID 11524702. 
• "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M. 
• "Release of cellular UDP-glucose as a potential extracellular signaling molecule". Mol. Pharmacol. 63 (5): 1190–1197. 2003. doi:10.1124/mol.63.5.1190. PMID 12695547. 
• "P2Y-like receptor, GPR105 (P2Y14), identifies and mediates chemotaxis of bone-marrowhematopoietic stem cells". Genes Dev. 17 (13): 1592–1604. 2003. doi:10.1101/gad.1071503. PMID 12842911. 
• "Human immature monocyte-derived dendritic cells express the G protein-coupled receptor GPR105 (KIAA0001, P2Y14) and increase intracellular calcium in response to its agonist, uridine diphosphoglucose". J. Immunol. 171 (4): 1941–1949. 2003. doi:10.4049/jimmunol.171.4.1941. PMID 12902497. 
• "GPR105, a novel Gi/o-coupled UDP-glucose receptor expressed on brain glia and peripheral immune cells, is regulated by immunologic challenge: possible role in neuroimmune function". Brain Res. Mol. Brain Res. 118 (1–2): 10–23. 2004. doi:10.1016/S0169-328X(03)00330-9. PMID 14559350. 

External links

• "P2Y Receptors: P2Y₁₄". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=3050. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.