Biology:P2RY11

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

P2Y purinoceptor 11 is a protein that in humans is encoded by the P2RY11 gene.

The product of this gene, P2Y₁₁, belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is coupled to the stimulation of the phosphoinositide and adenylyl cyclase pathways and behaves as a selective purinoceptor. Naturally occurring read-through transcripts, resulting from intergenic splicing between this gene and an immediately upstream gene (PPAN, encoding peter pan homolog), have been found. The PPAN-P2RY11 read-through mRNA is ubiquitously expressed and encodes a fusion protein that shares identity with each individual gene product.

See also

• P2Y receptor

Further reading

• "Signal transduction and white cell maturation via extracellular ATP and the P2Y11 receptor". Immunol. Cell Biol. 78 (4): 369–74. 2000. doi:10.1046/j.1440-1711.2000.00918.x. PMID 10947861. 
• Adams MD; Kerlavage AR; Fleischmann RD et al. (1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence". Nature 377 (6547 Suppl): 3–174. PMID 7566098. http://www.columbia.edu/itc/biology/pollack/w4065/client_edit/readings/nature377_3.pdf. 
• Communi D; Suarez-Huerta N; Dussossoy D et al. (2001). "Cotranscription and intergenic splicing of human P2Y11 and SSF1 genes". J. Biol. Chem. 276 (19): 16561–6. doi:10.1074/jbc.M009609200. PMID 11278528. 
• Moore DJ; Chambers JK; Wahlin JP et al. (2001). "Expression pattern of human P2Y receptor subtypes: a quantitative reverse transcription-polymerase chain reaction study". Biochim. Biophys. Acta 1521 (1–3): 107–19. doi:10.1016/S0167-4781(01)00291-3. PMID 11690642. 
• Duhant X; Schandené L; Bruyns C et al. (2002). "Extracellular adenine nucleotides inhibit the activation of human CD4+ T lymphocytes". J. Immunol. 169 (1): 15–21. doi:10.4049/jimmunol.169.1.15. PMID 12077223. 
• Strausberg RL; Feingold EA; Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M. 
• Gerhard DS; Wagner L; Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
• Moreschi I; Bruzzone S; Nicholas RA et al. (2006). "Extracellular NAD+ is an agonist of the human P2Y11 purinergic receptor in human granulocytes". J. Biol. Chem. 281 (42): 31419–29. doi:10.1074/jbc.M606625200. PMID 16926152. 
• "Structure and ligand-binding site characteristics of the human P2Y11 nucleotide receptor deduced from computational modelling and mutational analysis". Biochem. J. 405 (2): 277–86. 2007. doi:10.1042/BJ20061728. PMID 17338680. 

External links

• "P2Y Receptors: P2Y₁₁". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2400. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.