Biology:Neuromedin B receptor
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
The neuromedin B receptor (NMBR), now known as BB1 [1] is a G protein-coupled receptor whose endogenous ligand is neuromedin B.[2] In humans, this protein is encoded by the NMBR gene.
Neuromedin B receptor binds neuromedin B, a potent mitogen and growth factor for normal and neoplastic lung and for gastrointestinal epithelial tissue.[3]
References
- ↑ "Bombesin Receptors: BB1". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2956.
- ↑ "Expression and characterization of cloned human bombesin receptors". Mol. Pharmacol. 47 (1): 10–20. 1995. PMID 7838118. http://molpharm.aspetjournals.org/cgi/content/abstract/47/1/10.
- ↑ "Entrez Gene: NMBR neuromedin B receptor". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4829.
Further reading
- "Two distinct bombesin receptor subtypes are expressed and functional in human lung carcinoma cells.". J. Biol. Chem. 266 (28): 18771–9. 1991. doi:10.1016/S0021-9258(18)55129-2. PMID 1655761.
- "Differential activation of human gastrin-releasing peptide receptor-mediated responses by bombesin analogs.". Mol. Pharmacol. 47 (4): 871–81. 1995. PMID 7723750.
- "Expression and characterization of cloned human bombesin receptors.". Mol. Pharmacol. 47 (1): 10–20. 1995. PMID 7838118.
- "Expression of bombesin-receptor subtypes and their differential regulation of colonic smooth muscle contraction.". Gastroenterology 105 (6): 1672–80. 1994. doi:10.1016/0016-5085(93)91062-m. PMID 8253343.
- "Molecular cloning and characterization of receptors for the mammalian bombesin-like peptides.". J. Mol. Neurosci. 4 (1): 41–54. 1993. doi:10.1007/BF02736689. PMID 8391296.
- "The fifth transmembrane segment of the neuromedin B receptor is critical for high affinity neuromedin B binding.". J. Biol. Chem. 268 (20): 14622–6. 1993. doi:10.1016/S0021-9258(18)82378-X. PMID 8392057.
- "Bombesin-like peptide receptors in human bronchial epithelial cells.". Peptides 17 (1): 111–8. 1996. doi:10.1016/0196-9781(95)02088-8. PMID 8822519.
- "Four amino acid residues are critical for high affinity binding of neuromedin B to the neuromedin B receptor.". J. Biol. Chem. 273 (26): 15927–32. 1998. doi:10.1074/jbc.273.26.15927. PMID 9632639.
- "Solution structure of neuromedin B by (1)H nuclear magnetic resonance spectroscopy.". FEBS Lett. 460 (2): 263–9. 1999. doi:10.1016/S0014-5793(99)01346-0. PMID 10544247.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Neuromedin B and its receptor are mitogens in both normal and malignant epithelial cells lining the colon.". Am. J. Physiol. Gastrointest. Liver Physiol. 288 (4): G718–28. 2005. doi:10.1152/ajpgi.00156.2004. PMID 15528253.
External links
- "Bombesin Receptors: BB1". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2956.
- Receptors,+Bombesin at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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