Biology:GPR156
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
GPR156 (G protein-coupled receptor 156), is a human gene which encodes a G protein-coupled receptor belonging to metabotropic glutamate receptor subfamily.[1] By sequence homology, this gene was proposed as being a possible GABAB receptor subunit, however when expressed in cells alone or with other GABAB subunits, no response to GABAB ligands could be detected. Therefore, the function of this protein remains to be elucidated.[2] In vitro studies on GPR156 constitutive activity revealed a high level of basal activation and coupling with members of the Gi/Go heterotrimeric G protein family.[3]
References
- ↑ "Entrez Gene: GPR156 G protein-coupled receptor 156". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=165829.
- ↑ "Molecular cloning and characterisation of a novel GABAB-related G-protein coupled receptor". Brain Res. Mol. Brain Res. 110 (2): 305–17. 2003. doi:10.1016/S0169-328X(02)00662-9. PMID 12591167.
- ↑ Watkins, Lyndsay R.; Orlandi, Cesare (2021-03-30). "In vitro profiling of orphan G protein coupled receptor (GPCR) constitutive activity". British Journal of Pharmacology 178 (15): 2963–2975. doi:10.1111/bph.15468. ISSN 1476-5381. PMID 33784795.
Further reading
- "Molecular cloning and characterisation of a novel GABAB-related G-protein coupled receptor.". Brain Res. Mol. Brain Res. 110 (2): 305–17. 2003. doi:10.1016/S0169-328X(02)00662-9. PMID 12591167.
- "The G protein-coupled receptor repertoires of human and mouse.". Proc. Natl. Acad. Sci. U.S.A. 100 (8): 4903–8. 2003. doi:10.1073/pnas.0230374100. PMID 12679517. Bibcode: 2003PNAS..100.4903V.
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