Biology:LPAR3
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Lysophosphatidic acid receptor 3 also known as LPA3 is a protein that in humans is encoded by the LPAR3 gene.[1][2] LPA3 is a G protein-coupled receptor that binds the lipid signaling molecule lysophosphatidic acid (LPA).[3]
Function
This gene encodes a member of the G protein-coupled receptor family, as well as the EDG family of proteins. This protein functions as a cellular receptor for lysophosphatidic acid and mediates lysophosphatidic acid-evoked calcium mobilization. This receptor couples predominantly to G(q/11) alpha proteins.[1]
Evolution
Paralogues[4]
See also
References
- ↑ 1.0 1.1 "Entrez Gene: LPAR3 Lysophosphatidic acid receptor 3". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23566.
- ↑ "Molecular cloning and characterization of a novel human G-protein-coupled receptor, EDG7, for lysophosphatidic acid". J. Biol. Chem. 274 (39): 27776–85. September 1999. doi:10.1074/jbc.274.39.27776. PMID 10488122.
- ↑ "LPA Receptors: Subtypes and Biological Actions". Annual Review of Pharmacology and Toxicology 50 (1): 157–186. January 2010. doi:10.1146/annurev.pharmtox.010909.105753. PMID 20055701.
- ↑ "GeneCards®: The Human Gene Database". https://www.genecards.org/cgi-bin/carddisp.pl?gene=LPAR3&keywords=LPAR3#paralogs.
Further reading
- "Lysophosphatidic acid receptors.". Mol. Pharmacol. 58 (6): 1188–96. 2001. doi:10.1124/mol.58.6.1188. PMID 11093753.
- "Molecular cloning and characterization of a lysophosphatidic acid receptor, Edg-7, expressed in prostate.". Mol. Pharmacol. 57 (4): 753–9. 2000. doi:10.1124/mol.57.4.753. PMID 10727522.
- "Identification of an EDG7 variant, HOFNH30, a G-protein-coupled receptor for lysophosphatidic acid.". Biochem. Biophys. Res. Commun. 273 (3): 805–10. 2000. doi:10.1006/bbrc.2000.2943. PMID 10891327.
- "Human platelets respond differentially to lysophosphatidic acids having a highly unsaturated fatty acyl group and alkyl ether-linked lysophosphatidic acids.". Biochem. J. 365 (Pt 3): 617–28. 2002. doi:10.1042/BJ20020348. PMID 11982483.
- "Lysophosphatidic acid (LPA) receptors are activated differentially by biological fluids: possible role of LPA-binding proteins in activation of LPA receptors.". FEBS Lett. 523 (1–3): 187–92. 2002. doi:10.1016/S0014-5793(02)02976-9. PMID 12123830.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Modulation of myocardial contractility by lysophosphatidic acid (LPA).". J. Mol. Cell. Cardiol. 35 (1): 71–80. 2003. doi:10.1016/S0022-2828(02)00279-1. PMID 12623301.
- "Expression of lysophosphatidic acid receptors and vascular endothelial growth factor mediating lysophosphatidic acid in the development of human ovarian cancer.". Cancer Lett. 192 (2): 161–9. 2003. doi:10.1016/S0304-3835(02)00713-9. PMID 12668280.
- "Lysophosphatidic acid induces human natural killer cell chemotaxis and intracellular calcium mobilization.". Eur. J. Immunol. 33 (8): 2083–9. 2003. doi:10.1002/eji.200323711. PMID 12884281.
- "Cell density-dependent expression of EDG family receptors and mesangial cell proliferation: role in lysophosphatidic acid-mediated cell growth.". Am. J. Physiol. Renal Physiol. 287 (6): F1250–7. 2005. doi:10.1152/ajprenal.00342.2003. PMID 15292052.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
External links
- "Lysophospholipid Receptors: LPA3". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2992.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
 |  |
