Biology:GPR160

From HandWiki
Short description: Protein-coding gene in the species Homo sapiens

A representation of the 3D structure of the protein myoglobin showing turquoise α-helices.
Generic protein structure example

Probable G-protein coupled receptor 160 is a protein that in humans is encoded by the GPR160 gene.[1][2] It has been shown to be important in embryonic stem cell development, is involved in the perception of neuropathic pain, and is present in elevated levels in some cancers.[3][4][5][6] GPR160 has been suggested as the receptor for Cocaine- and amphetamine-regulated transcript, also known as CART.[7][8][9][10] However other research has since shown that it does not appear CART binds to GPR160 directly.[11][12] This suggests that an as yet unidentified target for CART may modulate GPR160 mediated responses indirectly under certain conditions, but without directly binding to the GPR160 receptor.

References

  1. ↑ "Identification of G protein-coupled receptor genes from the human genome sequence". FEBS Letters 520 (1–3): 97–101. June 2002. doi:10.1016/S0014-5793(02)02775-8. PMID 12044878. Bibcode: 2002FEBSL.520...97T. 
  2. ↑ "Entrez Gene: GPR160 G protein-coupled receptor 160". https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=26996. 
  3. ↑ "Downregulation of GPR160 inhibits the progression of glioma through suppressing epithelial to mesenchymal transition (EMT) biomarkers". Basic & Clinical Pharmacology & Toxicology 131 (4): 241–250. 2022. doi:10.1111/bcpt.13769. PMID 35771163. 
  4. ↑ "The Role of Cocaine- and Amphetamine-Regulated Transcript (CART) in Cancer: A Systematic Review". International Journal of Molecular Sciences 24 (12): 9986. 2023. doi:10.3390/ijms24129986. PMID 37373130. 
  5. ↑ "GPR160 regulates the self-renewal and pluripotency of mouse embryonic stem cells via JAK1/STAT3 signaling pathway". Journal of Genetics and Genomics 51 (10): 1055–1065. 2024. doi:10.1016/j.jgg.2024.05.003. PMID 38750952. 
  6. ↑ "Histone modifications and Sp1 promote GPR160 expression in bone cancer pain within rodent models". EMBO Reports 25 (12): 5429–5455. 2024. doi:10.1038/s44319-024-00292-6. PMID 39448865. 
  7. ↑ "GPR160 de-orphanization reveals critical roles in neuropathic pain in rodents". The Journal of Clinical Investigation 130 (5): 2587–2592. May 2020. doi:10.1172/JCI133270. PMID 31999650. 
  8. ↑ "GPR-160 Receptor Signaling in the Dorsal Vagal Complex of Male Rats Modulates Meal Microstructure and CART-Mediated Hypophagia". Nutrients 15 (10): 2268. 2023. doi:10.3390/nu15102268. PMID 37242151. 
  9. ↑ "Behavioral characterization of G-protein-coupled receptor 160 knockout mice". Pain 165 (6): 1361–1371. 2024. doi:10.1097/j.pain.0000000000003136. PMID 38198232. 
  10. ↑ "CARTp/GPR160 mediates behavioral hypersensitivities in mice through NOD2". Pain 166 (4): 902–915. 2025. doi:10.1097/j.pain.0000000000003418. PMID 39356206. 
  11. ↑ "GPR160 is not a receptor of anorexigenic cocaine- and amphetamine-regulated transcript peptide". European Journal of Pharmacology 949. 2023. doi:10.1016/j.ejphar.2023.175713. PMID 37054941. 
  12. ↑ "High expression of GPR160 in prostate cancer is unrelated to CARTp-mediated signaling pathways". Acta Pharmaceutica Sinica B 14 (3): 1467–1471. 2024. doi:10.1016/j.apsb.2023.11.025. PMID 38487007. 

Further reading

  • "Mining of assembled expressed sequence tag (EST) data for protein families: application to the G protein-coupled receptor superfamily". Briefings in Bioinformatics 1 (1): 93–99. February 2000. doi:10.1093/bib/1.1.93. PMID 11466977. 



Retrieved from "https://handwiki.org/wiki/index.php?title=Biology:GPR160&oldid=4085704"