Biology:Neuropeptide Y receptor Y1

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Neuropeptide Y receptor type 1 is a protein that in humans is encoded by the NPY1R gene.

Selective ligands

Agonists

• Neuropeptide Y (endogenous agonist, non subtype selective)
• Peptide YY

Antagonists

Peptide

• BVD-10 (selective NPY₁ antagonist, CAS# 262418-00-8)
• GR-231,118 (mixed NPY₁ antagonist / NPY₄ agonist, CAS# 158859-98-4)

Non-peptide

• BIBO-3304 (CAS# 191868-14-1)
• BIBP-3226 (CAS# 159013-54-4)
• PD-160,170 (CAS# 181468-88-2)

Available Structures

• 5ZBH (Neuropeptide Y1 bound to antagonist BMS-193835)
• 5ZBQ (Neuropeptide Y1 bound to antagonist UR-MK299)

See also

• Neuropeptide Y receptor

Further reading

• "Neuropeptide Y receptor subtypes". Life Sciences 56 (13): 1055–64. February 1995. doi:10.1016/0024-3205(95)00041-4. PMID 9001438. 
• "Neuropeptide Y receptors as targets for anti-obesity drug development: perspective and current status". European Journal of Pharmacology 440 (2–3): 173–87. April 2002. doi:10.1016/S0014-2999(02)01427-9. PMID 12007534. 
• "Biophysical methods to study ligand-receptor interactions of neuropeptide Y". Biopolymers 60 (6): 420–37. 2002. doi:10.1002/1097-0282(2001)60:6<420::AID-BIP10183>3.0.CO;2-W. PMID 12209475. 
• "Cloning and functional expression of a human neuropeptide Y/peptide YY receptor of the Y1 type". The Journal of Biological Chemistry 267 (16): 10935–8. June 1992. doi:10.1016/S0021-9258(19)49854-2. PMID 1317848. 
• "Cloned human neuropeptide Y receptor couples to two different second messenger systems". Proceedings of the National Academy of Sciences of the United States of America 89 (13): 5794–8. July 1992. doi:10.1073/pnas.89.13.5794. PMID 1321422. Bibcode: 1992PNAS...89.5794H. 
• "Cloning and functional expression of a cDNA encoding a human type 2 neuropeptide Y receptor". The Journal of Biological Chemistry 270 (39): 22661–4. September 1995. doi:10.1074/jbc.270.39.22661. PMID 7559383. 
• "Rapid internalization and recycling of the human neuropeptide Y Y(1) receptor". The Journal of Biological Chemistry 277 (8): 6645–55. February 2002. doi:10.1074/jbc.M107224200. PMID 11741903. 
• "Predominant role by CaM kinase in NPY Y(1) receptor signaling: involvement of CREB [corrected]". Peptides 23 (1): 87–96. January 2002. doi:10.1016/S0196-9781(01)00583-6. PMID 11814622. 
• "Neuropeptide Y, Y1, Y2 and Y4 receptors mediate Y agonist responses in isolated human colon mucosa". British Journal of Pharmacology 135 (6): 1505–12. March 2002. doi:10.1038/sj.bjp.0704604. PMID 11906964. 
• "Neuropeptide Y Y1 and neuropeptide Y Y2 receptors in human cardiovascular tissues". Peptides 23 (5): 927–34. May 2002. doi:10.1016/S0196-9781(02)00003-7. PMID 12084524. 
• "Y1 receptor of neuropeptide Y as a glial marker in proliferative vitreoretinopathy and diseased human retina". Glia 39 (3): 320–4. September 2002. doi:10.1002/glia.10107. PMID 12203398. 
• "The use of bioluminescence resonance energy transfer 2 to study neuropeptide Y receptor agonist-induced beta-arrestin 2 interaction". The Journal of Pharmacology and Experimental Therapeutics 306 (1): 147–56. July 2003. doi:10.1124/jpet.103.051227. PMID 12665544. 
• "A protein interaction framework for human mRNA degradation". Genome Research 14 (7): 1315–23. July 2004. doi:10.1101/gr.2122004. PMID 15231747. 
• "High expression of neuropeptide y receptors in tumors of the human adrenal gland and extra-adrenal paraganglia". Clinical Cancer Research 10 (24): 8426–33. December 2004. doi:10.1158/1078-0432.CCR-04-0821. PMID 15623622. 

External links

• "Neuropeptide Y Receptors: Y₁". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2366. 
• Overview of all the structural information available in the PDB for UniProt: P25929 (Neuropeptide Y receptor type 1) at the PDBe-KB.