Biology:GPR52

From HandWiki
Short description: Protein-coding gene in the species Homo sapiens


A representation of the 3D structure of the protein myoglobin showing turquoise α-helices.
Generic protein structure example

Probable G-protein coupled receptor 52 is a protein that in humans is encoded by the GPR52 gene.[1][2]

Members of the G protein-coupled receptor (GPR) family play important roles in signal transduction from the external environment to the inside of the cell.[supplied by OMIM][2]

Cannabidiol, CBD, and O-1918 are Inverse agonist at GPR52[3]

References

  1. "Identification and cloning of three novel human G protein-coupled receptor genes GPR52, PsiGPR53 and GPR55: GPR55 is extensively expressed in human brain". Brain Res Mol Brain Res 64 (2): 193–8. Mar 1999. doi:10.1016/S0169-328X(98)00277-0. PMID 9931487. 
  2. 2.0 2.1 "Entrez Gene: GPR52 G protein-coupled receptor 52". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9293. 
  3. Stott, Lisa A.; Brighton, Cheryl A.; Brown, Jason; Mould, Richard; Bennett, Kirstie A.; Newman, Robert; Currinn, Heather; Autore, Flavia et al. (2021-06-01). "Characterisation of inverse agonism of the orphan-G protein-coupled receptor GPR52 by cannabinoid ligands Cannabidiol and O-1918". Heliyon 7 (6): e07201. doi:10.1016/j.heliyon.2021.e07201. ISSN 2405-8440. PMID 34189291. 

Further reading