Biology:GPR158
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Probable G-protein coupled receptor 158 (GPR158), also known as the metabotropic glycine receptor (mGlyR),[1] is a protein that in humans is encoded by the GPR158 gene.[2]
Function
This protein is an orphan class C GPCR. It is highly expressed in the brain, where it binds to RGS7, an inhibitor of Gi/o-coupled GPCR signaling, localizing it to the plasma membrane.[3]
It is expressed at lower levels in other organs and shows an unusual subcellular localization pattern, being found at both the plasma membrane and in the nucleus.[4]
Clinical significance
Role in mood regulation
GPR158 in the medial prefrontal cortex (mPFC) has been shown to regulate stress-induced depression in a mouse model of depression and has been found to be upregulated in post-mortem tissue samples from humans with major depressive disorder (MDD).[5]
Role in prostate cancer
The GPR158 gene is an androgen-regulated gene that stimulates cell proliferation in prostate cancer cell lines, and it is linked to neuroendocrine differentiation.[6]
References
- ↑ "Orphan receptor GPR158 serves as a metabotropic glycine receptor: mGlyR". Science 379 (6639): 1352–1358. March 2023. doi:10.1126/science.add7150. PMID 36996198.
- ↑ "Entrez Gene: GPR158 G protein-coupled receptor 158". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=57512.
- ↑ "GPR158/179 regulate G protein signaling by controlling localization and activity of the RGS7 complexes". J. Cell Biol. 197 (6): 711–9. 2012. doi:10.1083/jcb.201202123. PMID 22689652.
- ↑ "GPR158, an orphan member of G protein-coupled receptor Family C: glucocorticoid-stimulated expression and novel nuclear role". PLOS ONE 8 (2): e57843. 2013. doi:10.1371/journal.pone.0057843. PMID 23451275. Bibcode: 2013PLoSO...857843P.
- ↑ "Orphan receptor GPR158 controls stress-induced depression". eLife 7. 2018. doi:10.7554/eLife.33273.001. PMID 29419376.
- ↑ "Expression and functional role of orphan receptor GPR158 in prostate cancer growth and progression". PLOS ONE 10 (2): e0117758. 2015. doi:10.1371/journal.pone.0117758. PMID 25693195. Bibcode: 2015PLoSO..1017758P.
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