Biology:GPR120
 Generic protein structure example |
G-protein coupled receptor 120 is a protein that in humans is encoded by the GPR120 gene.[1][2]
GPR120 is a member of the rhodopsin family of G protein-coupled receptors (GPRs).[1][2]
GPR120 has also been shown to mediate the anti-inflammatory and insulin-sensitizing effects of omega 3 fatty acids.[3] Lack of GPR120 is responsible for reduced fat metabolism, thereby leading to obesity.[4]
Additionally, GPR120 has been implicated to be involved in the ability to taste fats.[5] It is expressed in taste bud cells (specifically cell type II, which contain other G-protein coupled taste receptors), and its absence leads to reduced preference to two types of fatty acid (linoleic acid and oleic acid), as well as decreased neuronal response to oral fatty acids.[6]
References
- ↑ 1.0 1.1 "Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives". FEBS Lett 554 (3): 381–8. Nov 2003. doi:10.1016/S0014-5793(03)01196-7. PMID 14623098.
- ↑ 2.0 2.1 "Entrez Gene: GPR120 G protein-coupled receptor 120". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=338557.
- ↑ "GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects". Cell 142 (5): 687–698. 2010. doi:10.1016/j.cell.2010.07.041. PMID 20813258.
- ↑ "Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human". Nature 483 (7389): 350–4. 2012. doi:10.1038/nature10798. PMID 22343897. Bibcode: 2012Natur.483..350I. https://repository.kulib.kyoto-u.ac.jp/dspace/bitstream/2433/153278/1/nature10798.pdf.
- ↑ Dipatrizio, N. V. (2014). "Is fat taste ready for primetime?". Physiology & Behavior 136: 145–54. doi:10.1016/j.physbeh.2014.03.002. PMID 24631296.
- ↑ "Taste preference for fatty acids is mediated by GPR40 and GPR120". J Neurosci 30 (25): 8376–82. 2010. doi:10.1523/JNEUROSCI.0496-10.2010. PMID 20573884.
Further reading
- "The G protein-coupled receptor repertoires of human and mouse". Proc. Natl. Acad. Sci. U.S.A. 100 (8): 4903–8. 2003. doi:10.1073/pnas.0230374100. PMID 12679517. Bibcode: 2003PNAS..100.4903V.
- "Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120". Nat. Med. 11 (1): 90–4. 2005. doi:10.1038/nm1168. PMID 15619630.
- "Transcriptome analysis of human gastric cancer". Mamm. Genome 16 (12): 942–54. 2006. doi:10.1007/s00335-005-0075-2. PMID 16341674.
 |
