Biology:FZD8

Generic protein structure example

Frizzled-8 is a protein that in humans is encoded by the FZD8 gene.

Function

This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This gene is highly expressed in two human cancer cell lines, indicating that it may play a role in several types of cancer. The crystal structure of the extracellular cysteine-rich domain of a similar mouse protein has been determined.

See also

• Frizzled

Further reading

• "A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled". J. Biol. Chem. 271 (8): 4468–4476. 1996. doi:10.1074/jbc.271.8.4468. PMID 8626800. 
• "Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action". Proc. Natl. Acad. Sci. U.S.A. 94 (13): 6770–6775. 1997. doi:10.1073/pnas.94.13.6770. PMID 9192640. Bibcode: 1997PNAS...94.6770F. 
• "LDL-receptor-related proteins in Wnt signal transduction". Nature 407 (6803): 530–535. 2000. doi:10.1038/35035117. PMID 11029007. Bibcode: 2000Natur.407..530T. 
• "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–1795. 2001. doi:10.1101/gr.143000. PMID 11076863. 
• "Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6". Curr. Biol. 11 (12): 951–961. 2001. doi:10.1016/S0960-9822(01)00290-1. PMID 11448771. 
• "Insights into Wnt binding and signalling from the structures of two Frizzled cysteine-rich domains". Nature 412 (6842): 86–90. 2001. doi:10.1038/35083601. PMID 11452312. Bibcode: 2001Natur.412...86D. 
• "Identification of a PDZ domain containing Golgi protein, GOPC, as an interaction partner of frizzled". Biochem. Biophys. Res. Commun. 286 (4): 771–778. 2001. doi:10.1006/bbrc.2001.5430. PMID 11520064. 
• "Autosomal dominant familial exudative vitreoretinopathy in two Japanese families with FZD4 mutations (H69Y and C181R)". Ophthalmic Genet. 25 (2): 81–90. 2004. doi:10.1080/13816810490514270. PMID 15370539. 
• "Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth". Cell 119 (1): 97–108. 2004. doi:10.1016/j.cell.2004.09.019. PMID 15454084. 

External links

• "Frizzled Receptors: FZD₈". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=3066. 
• Overview of all the structural information available in the PDB for UniProt: Q9H461 (Human Frizzled-8 (FZD8)) at the PDBe-KB.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.