Biology:GPR12
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Probable G-protein coupled receptor 12 is a protein that in humans is encoded by the GPR12 gene.[1][2][3]
The gene product of GPR12 is an orphan receptor, meaning that its endogenous ligand is currently unknown. Gene disruption of GPR12 in mice results in dyslipidemia and obesity.[4]
Ligands
- Inverse agonists
Evolution
Paralogues
Source:[6]
References
- ↑ "Molecular cloning of a novel putative G protein-coupled receptor (GPCR21) which is expressed predominantly in mouse central nervous system". FEBS Letters 336 (2): 317–22. December 1993. doi:10.1016/0014-5793(93)80828-I. PMID 8262253.
- ↑ "Molecular cloning and chromosomal localization of human genes encoding three closely related G protein-coupled receptors". Genomics 28 (2): 347–9. July 1995. doi:10.1006/geno.1995.1154. PMID 8530049. https://zenodo.org/record/1229665.
- ↑ "Entrez Gene: GPR12 G protein-coupled receptor 12". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2835.
- ↑ "G protein-coupled receptor 12 deficiency results in dyslipidemia and obesity in mice". Biochemical and Biophysical Research Communications 348 (2): 359–66. September 2006. doi:10.1016/j.bbrc.2006.07.090. PMID 16887097.
- ↑ "Cannabidiol, a novel inverse agonist for GPR12". Biochemical and Biophysical Research Communications 493 (1): 451–454. November 2017. doi:10.1016/j.bbrc.2017.09.001. PMID 28888984.
- ↑ "GeneCards®: The Human Gene Database". https://www.genecards.org/cgi-bin/carddisp.pl?gene=GPR12#paralogs.
Further reading
- "Fluid shear stress differentially regulates gpr3, gpr6, and gpr12 expression in human umbilical vein endothelial cells". Cellular Physiology and Biochemistry 13 (2): 75–84. 2003. doi:10.1159/000070251. PMID 12649592.
 |  |
