Biology:Glucagon-like peptide-2 receptor

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Glucagon-like peptide-2 receptor (GLP-2R) is a protein that in human is encoded by the GLP2R gene located on chromosome 17.

Function

The GLP2 receptor (GLP2R) is a G protein-coupled receptor superfamily member closely related to the glucagon receptor (GLP1 receptor). Glucagon-like peptide-2 (GLP2) is a 33-amino acid proglucagon-derived peptide produced by intestinal enteroendocrine cells. Like glucagon-like peptide-1 (GLP1) and glucagon itself, it is derived from the proglucagon peptide encoded by the GCG gene. GLP2 stimulates intestinal growth and upregulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. Moreover, GLP2 prevents intestinal hypoplasia resulting from total parenteral nutrition. GLP2R, a G protein-coupled receptor superfamily member is expressed in the gut and closely related to the glucagon receptor (GCGR) and the receptor for GLP1 (GLP1R).

See also

• Glucagon-like peptide-2

Further reading

• "Glucagon-like peptide 2: a nutrient-responsive gut growth factor". The Journal of Nutrition 131 (3): 709–12. Mar 2001. doi:10.1093/jn/131.3.709. PMID 11238747. 
• "Prototypic G protein-coupled receptor for the intestinotrophic factor glucagon-like peptide 2". Proceedings of the National Academy of Sciences of the United States of America 96 (4): 1569–73. Feb 1999. doi:10.1073/pnas.96.4.1569. PMID 9990065. Bibcode: 1999PNAS...96.1569M. 
• "Enteroendocrine localization of GLP-2 receptor expression in humans and rodents". Gastroenterology 119 (3): 744–55. Sep 2000. doi:10.1053/gast.2000.16489. PMID 10982769. 
• "The truncated metabolite GLP-2 (3-33) interacts with the GLP-2 receptor as a partial agonist". Regulatory Peptides 103 (1): 9–15. Jan 2002. doi:10.1016/S0167-0115(01)00316-0. PMID 11738243. 
• "The HeLa cell glucagon-like peptide-2 receptor is coupled to regulation of apoptosis and ERK1/2 activation through divergent signaling pathways". Molecular Endocrinology 19 (2): 459–73. Feb 2005. doi:10.1210/me.2004-0196. PMID 15471943. 
• "GLP-2 stimulates colonic growth via KGF, released by subepithelial myofibroblasts with GLP-2 receptors". Regulatory Peptides 124 (1–3): 105–12. Jan 2005. doi:10.1016/j.regpep.2004.07.009. PMID 15544847. 
• "Calmodulin interacts with the cytoplasmic tails of the parathyroid hormone 1 receptor and a sub-set of class b G-protein coupled receptors". FEBS Letters 579 (3): 803–7. Jan 2005. doi:10.1016/j.febslet.2004.12.056. PMID 15670850. 
• "The glucagon-like peptide-2 receptor C terminus modulates beta-arrestin-2 association but is dispensable for ligand-induced desensitization, endocytosis, and G-protein-dependent effector activation". The Journal of Biological Chemistry 280 (23): 22124–34. Jun 2005. doi:10.1074/jbc.M500078200. PMID 15817468. 
• "GLP-2 receptor localizes to enteric neurons and endocrine cells expressing vasoactive peptides and mediates increased blood flow". Gastroenterology 130 (1): 150–64. Jan 2006. doi:10.1053/j.gastro.2005.11.005. PMID 16401478. http://www.gastrojournal.org/article/S0016508505022651/pdf. 
• "Naturally occurring glucagon-like peptide-2 (GLP-2) receptors in human intestinal cell lines". European Journal of Pharmacology 532 (1–2): 18–23. Feb 2006. doi:10.1016/j.ejphar.2005.12.001. PMID 16448646. 
• "Glucagon Receptor Family: GLP-2". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2291. 

External links

• Glucagon-Like Peptide-2 Receptor at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.